货号：06-1130

品牌：Merck Millipore

规格：EA

目录价：￥3920.00

市场价格：￥3332.00

会员价格：￥3136.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RNF168 Antibody | 06-1130 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes RNF168 at the C-terminus. View All» Molecular Weight: ~79 kDa observed. View All» Epitope: C-terminus View All» Immunogen: Histidine-tagged recombinant protein corresponding to the C-terminus of human RNF168. View All» Background Information: RNF168 is a ubiquitin ligand that binds to ubiquinated histone H2A and localizes to sites of DNA damage. RNF168-dependent chromatin modifications cause 53BP1 and BRCA1 to accumulated at the site. A mutation in RNF168 has been associated with RIDDLE syndrome, an immunodeficiency and radiosensitivity disorder. RNF168 is responsible for securing repair factors at sites of DNA damage. RNF168 has two MIU (motif interacting with ubiquitin) and one UMI (UIM- and MIU-related UBD) ubiquitin binding domains (UBDs) which are essential for proper localization of RNF168. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. View All» Control: Jurkat cell lysate View All» Quality Assurance: Evaluated by Western Blot in Jurkat cell lysate.Western Blot Analysis: 0.1 µg/mL of this antibody detected RNF168 on 10 µg of Jurkat cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q8IYW5 View All» Entrez Gene Number: NP_689830 View All» Gene Symbol: RNF168 View All» Alternate Names:

• E3 ubiquitin-protein ligase RNF168

• RING finger protein 168
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The complex repair response elicited by DNA double-strand breaks (DSBs) includes recruitment of several DNA repair proteins and ubiquitination of H2A-type histones (see MIM 142720). RNF168 is an E3 ubiquitin ligase critical for DSB repair (Stewart et al., 2009 [PubMed 19203578]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. PATHWAY: Protein modification; protein ubiquitination.SUBUNIT STRUCTURE: Interacts with UBE2N/UBC13. SUBCELLULAR LOCATION: Nucleus. Note: Localizes to sites of DNA damage. DOMAIN: The MIU motifs (motif interacting with ubiquitin) mediate the interaction with ubiquitin and the localization at sites of DNA damage.INVOLVEMENT IN DISEASE: Defects in RNF168 are the cause of Riddle syndrome (RIDDLES) [MIM:611943]. Riddle syndrome is characterized by increased radiosensitivity, immunodeficiency, mild motor control and learning difficulties, facial dysmorphism, and short stature. Defects are probably due to impaired localization of TP53BP1 and BRCA1 at DNA lesions. SEQUENCE SIMILARITIES: Belongs to the RNF168 family.Contains 1 RING-type zinc finger.SEQUENCE CAUTION: The sequence BAB70801.1 differs from that shown. Reason: Erroneous initiation. The sequence BAC04060.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-RNF168 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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