货号：06-1291

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Hexim1 Antibody | 06-1291 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Hexim1. View All» Molecular Weight: ~40 kDa (predicted).Molecular weight Note: According to an independent laboratory, the two isoforms of Hexim1 run at ~53 kDa & ~68 kDa. This antibody can detect the ~53 kDa isoform in multiple cells. View All» Immunogen: His-tagged recombinant protein corresponding to human Hexim1. View All» Background Information: Hexim1 is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. Hexim1 works in cooperation with 7SK snRNA to sequester P-TEFb in a large inactive 7SK snRNP complex, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. Hexim1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. The 7SK snRNP complex is composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), Hexim1, Hexim2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Hexim1 also interacts with the N-CoR complex through NCOR1, ESR1, NR3C1, and may interact with NF-kappa-B through REL A. Hexim1 is located in the nucleus where it can bind with alpha-importin, and can also be found in the cytoplasm. Hexim1 is up-regulated by HMBA (hexamethylene bisacetamide) at the protein level and down-regulated by estrogen. View All» Species Reactivity: Human View All» Species Reactivity Note: Proven to react with human. Mouse (85% sequence homology) and rat (86% sequence homology). View All» Application Notes: Western Blot Analysis: A 1:1,000 dilution from a previous lot detected Hexim1 in 10 µg of HeLa cell lysate. View All» Control: HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa cell lysate.Western Blot Analysis: A 1:1,000 dilution of this antibody detected Hexim1 in 10 µg of HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Sheep polyclonal serum containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: O94992 View All» Entrez Gene Number: NP_006451.1 View All» Gene Symbol:

• CLP-1

• CLP1

• EDG1

• FLJ13562

• HIS1

• HMBA-inducible

• MAQ1
  View All» Alternate Names:
  • Cardiac lineage protein 1

  • Estrogen down-regulated gene 1 protein

  • Hexamethylene bis-acetamide-inducible protein 1

  • Menage a quatre protein 1

  • hexamethylene bis-acetamide inducible 1

  • hexamethylene bisacetamide-inducible protein

  • hexamethylene-bis-acetamide-inducible transcript 1

  • hexamthylene bis-acetamide inducible 1

  • menage a quatre 1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Expression of this gene is induced by hexamethylene-bis-acetamide in vascular smooth muscle cells. This gene has no introns. View All» UniProt Summary: FUNCTION: Transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. May also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity. SUBUNIT STRUCTURE: Homooligomer and heterooligomer with HEXIM2; probably dimeric. Component of the 7SK snRNP complex at least composed of P-TEFb (composed of CDK9 and CCNT1/cyclin-T1), HEXIM1, HEXIM2, BCDIN3, SART3 proteins and 7SK and U6 snRNAs. Interacts with the N-CoR complex through NCOR1. Interacts with ESR1 and NR3C1. May interact with NF-kappa-B through RELA. SUBCELLULAR LOCATION: Nucleus. Cytoplasm. Note: Binds alpha-importin and is mostly nuclear. TISSUE SPECIFICITY: Ubiquitously expressed with higher expression in placenta. HEXIM1 and HEXIM2 are differentially expressed. Expressed in endocrine tissues. INDUCTION: Up-regulated by HMBA (hexamethylene bisacetamide) (at protein level). Down-regulated by estrogen. DOMAIN: The coiled-coil domain mediates oligomerization.MISCELLANEOUS: Inhibits Tat activity which is required for HIV-1 transcription.SEQUENCE SIMILARITIES: Belongs to the HEXIM family. View All» Product Name: Anti-Hexim1 Antibody (06-1291) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Sheep View All»
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