货号：06-1292

品牌：Merck Millipore

规格：100UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Cep63 Antibody | 06-1292 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~63 kDa observed. Different isoforms or uncharacterized bands may be observed in some endogenous cell lysates. Experiments using transfected cells and siRNA have confirmed detection of Cep63. View All» Immunogen: Recombinant protein corresponding to human Cep63. View All» Background Information: Centrosomal protein 63 (Cep63) serves an ATM and ATR substrate for spindle assembly activation following chromosomal breakage. It is shown that inactivation of the CEP63 gene in avian DT40 cells impairs spindle assembly and prevents ATM- and ATR-dependent effects on mitosis. Cep63 is also reported to bind to and recruit Cdk1 to centrosomes and is thought to be involved the regulation mitotoic entry, centrosome amplification, and genome maintentance. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. View All» Application Notes: Immunocytochemistry Analysis: A representative lot detected Cep63 in U20S cells. (Nicola Brown, CRUK Clare Hall Laboratories, London, UK) View All» Control: HEK 293 cell lysate View All» Quality Assurance: Evaluated by Western Blot in HEK293 cell lysate.Western Blot Analysis: A 1: 500 dilution of this antibody detected Cep63 in 10 µg of HEK 293 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96MT8 View All» Entrez Gene Number: NP_001035842.1 View All» Gene Symbol: CEP63 View All» Alternate Names: Centrosomal protein of 63 kDa View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Western Blotting

  • Immunocytochemistry
    View All» Entrez Gene Summary: This gene encodes a protein with six coiled-coil domains. The protein is localized to the centrosome, a non-membraneous organelle that functions as the major microtubule-organizing center in animal cells. Several alternatively spliced transcript variants have been found, but their biological validity has not been determined. View All» UniProt Summary: FUNCTION: Required for normal spindle assembly. Plays a role in DNA damage response: following DNA double strand breaks (DSBs), it is delocalized from centrosomes, leading to inactivate spindle assembly and delay mitotic progression By similarity.SUBCELLULAR LOCATION: Cytoplasm > cytoskeleton > centrosome.SEQUENCE SIMILARITIES: Belongs to the CEP63 family. View All» Product Name: Anti-Cep63 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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