货号：06-1300

品牌：Merck Millipore

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目录价：￥4264.00

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金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RuvB-like 2 Antibody | 06-1300 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~51 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human RuvB-like 2. View All» Background Information: RuvB-like 2 (RUVBL2), also called Reptin 52 and TIP49B, is a DNA helicase of the AAA+ ATPase family known to be involved in double-strand break repair. The RuvB-Like 2 is the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. In mammalian cells, functional analysis of the RevB-like 2 protein has shown it functions as both and DNA-stimulated ATPase and an ATP-dependent DNA helicase. As a component of the NuA4 histone acetyltransferase complex this protein acetylates histones H4 and H2A to activate transcription. These changes appear to alter nucleosome-DNA interactions and promote the interactions of other proteins that activate transcription. Activation by this complex may be required for activation of genes associated with with tumor suppressor mediated growth arrest, apoptosis, DNA repair, as well as oncogene and proto-oncogene mediated growth induction. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human, Mouse, and Rat. View All» Control: Human testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected RuvB-like 2 on 10 µg of human testis tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q9Y230 View All» Entrez Gene Number: NP_006657 View All» Gene Symbol:
  • ECP-51

  • TIP48

  • TAP54-beta

  • ECP51

  • INO80

  • TIH2

  • RVB2

  • Rvb2

  • TIP49b
    View All» Alternate Names:
    • RuvB-like 2 (E. coli)

    • TIP60-associated protein 54-beta

    • 48 kDa TATA box-binding protein-interacting protein

    • INO80 complex subunit J

    • 51 kDa erythrocyte cytosolic protein

    • Reptin52

    • RuvB (E coli homolog)-like 2

    • REPTIN

    • ruvB-like 2

    • Reptin 52

    • TBP-interacting protein, 48-KD

    • Repressing pontin 52

    • erythrocyte cytosolic protein, 51-KD

    • 48 kDa TBP-interacting protein
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes the second human homologue of the bacterial RuvB gene. Bacterial RuvB protein is a DNA helicase essential for homologous recombination and DNA double-strand break repair. Functional analysis showed that this gene product has both ATPase and DNA helicase activities. This gene is physically linked to the CGB/LHB gene cluster on chromosome 19q13.3, and is very close (55 nt) to the LHB gene, in the opposite orientation. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May also inhibit the transcriptional activity of ATF2. CATALYTIC ACTIVITY: ATP + H2O = ADP + phosphate.SUBUNIT STRUCTURE: Forms a multimeric complex with RUVBL1. Interacts with the transcriptional activation domain of MYC. Interacts With ATF2. Component of the RNA polymerase II holoenzyme complex. May also act to bridge the LEF1/TCF1-CTNNB1 complex and TBP. Component of the NuA4 histone acetyltransferase complex which contains the catalytic subunit KAT5/TIP60 and the subunits EP400, TRRAP/PAF400, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, ING3, actin, ACTL6A/BAF53A, MORF4L1/MRG15, MORF4L2/MRGX, MRGBP, YEATS4/GAS41, VPS72/YL1 and MEAF6. The NuA4 complex interacts with MYC and the adenovirus E1A protein. RUVBL2 interacts with EP400. Component of a NuA4-related complex which contains EP400, TRRAP/PAF400, SRCAP, BRD8/SMAP, EPC1, DMAP1/DNMAP1, RUVBL1/TIP49, RUVBL2, actin, ACTL6A/BAF53A, VPS72 and YEATS4/GAS41. Interacts with NPAT. Component of the chromatin-remodeling INO80 complex, at least composed of ACTL6A, ACTR5, ACTR8, RVBL1, RVBL2, INO80, INO80B, INO80C, INO80D and INO80E. Component of some MLL1/MLL complex, at least composed of the core components MLL, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components C17orf49, CHD8, E2F6, HSP70, IN80C, KIAA1267, LAS1L, MAX, MCRS1, MGA, MYST1/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with IGHMBP2. SUBCELLULAR LOCATION: Nucleus matrix. Nucleus › nucleoplasm. Cytoplasm. Membrane. Note: Mainly localized in the nucleus, associated with nuclear matrix or in the nuclear cytosol. Although it is also present in the cytoplasm and associated with the cell membranes.TISSUE SPECIFICTY: Ubiquitously expressed. Highly expressed in testis and thymus.DOMAIN: The C-terminal domain is required for association with ATF2.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SEQUENCE SIMILARITIES: Belongs to the ruvB family.SEQUENCE CAUTION: The sequence AAD34041.1 differs from that shown. Reason: Frameshift at position 401. The sequence AAH08355.1 differs from that shown. Reason: Frameshift at position 191. View All» Product Name: Anti-RuvB-like 2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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