货号：06-1306

品牌：Merck Millipore

规格：100UL

目录价：￥5331.00

市场价格：￥4531.35

会员价格：￥4264.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mi-2b (CHD4) Antibody | 06-1306 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes CHD-4 at the N-terminus. View All» Molecular Weight: 217 kDa View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to mouse CHD-4 at and around the N-terminus. View All» Background Information: CHD-4 is also often referred to as Mi2-beta. This protein is a central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. CHD4 has been shown to interact with TRIM27, HDAC1, Histone deacetylase 2, MTA2, SATB1 and Ataxia telangiectasia and Rad3 related. This protein also interacts with KLF1. This interaction which depends on sumoylation of KLF1 leads to its transcriptional repression. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Proven to react with human. Predicted to react with mouse based on 100% sequence homology. Rat (96%). View All» Control: HeLa nuclear extract cell lysate View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected CHD-4 on 10 µg of HeLa nuclear extract cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal in serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: Q6PDQ2 View All» Entrez Gene Number: NP_666091.1 View All» Gene Symbol:
  • CHD4

  • CHD-4

  • Mi-2b

  • Mi2-BETA

  • Mi2-beta
    View All» Alternate Names:
    • ATP-dependent helicase CHD4

    • Mi-2 autoantigen 218 kDa protein

    • chromodomain helicase DNA binding protein 4
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The product of this gene belongs to the SNF2/RAD54 helicase family. It represents the main component of the nucleosome remodeling and deacetylase complex and plays an important role in epigenetic transcriptional repression. Patients with dermatomyositis develop antibodies against this protein. View All» UniProt Summary: FUNCTION: Probable transcription regulator by similarity.SUBUNIT STRUCTURE: Central component of the nucleosome remodeling and histone deacetylase (NuRD) repressor complex. Interacts with TRIM27. Interacts with ZGPAT; the interaction is direct. Part of a complex containing ATR and HDAC2 By similarity. Interacts with KLF1; the interaction depends on sumoylation of KLF1, and leads to its transcriptional repression. Interacts directly with IKFZ1 in the NuRD complex.SUBCELLULAR LOCATION: Nucleus By similarity. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR by similarity.SEQUENCE SIMLARITIES: Belongs to the SNF2/RAD54 helicase family.Contains 2 chromo domains.Contains 1 helicase ATP-binding domain.Contains 1 helicase C-terminal domain.Contains 2 PHD-type zinc fingers. View All» Product Name: Anti-Mi-2b (CHD4) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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