货号：06-1310

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-JAK2 Antibody | 06-1310 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the protein kinase 1 domain of JAK2. View All» Molecular Weight: ~130 kDa View All» Epitope: Protein kinase 1 domain View All» Immunogen: KLH-conjugated linear peptide corresponding to the protein kinase 1 domain of mouse JAK2. View All» Background Information: The Janus family of tyrosine kinases (JAK) includes JAK1, JAK2, JAK3 and Tyk2. This family associates with a variety of cytokine receptors and is activated by ligand binding. Upon ligand binding to cytokine receptors, JAKs phosphorylate themselves and their associated receptors. This provides multiple binding sites for signaling proteins containing SH2 or other phospho-tyrosine-binding domains, including STATs, Shc, insulin receptor substrates and FAK. View All» Species Reactivity:

• Mouse

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Western Blot Analysis: 1 µg/mL from a previous lot detected JAK2 in 10 µg of L6 cell lysate.Immunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated JAK2 from RAW264.7 cell lysate. View All» Control: RAW264.7 cell lysate View All» Quality Assurance: Evaluated by Western Blot in RAW264.7 cell lysate.Western Blot Analysis: 0.5 µg/mL of this antibody detected JAK2 in 10 µg of RAW264.7 cell lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q62120 View All» Entrez Gene Number: NP_001041642 View All» Gene Symbol:
  • JAK2

  • JAK-2
    View All» Alternate Names:
    • Janus kinase 2

    • Janus kinase 2 (a protein tyrosine kinase)

    • tyrosine-protein kinase JAK2
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunoprecipitation
        View All» UniProt Summary: FUNCTION: Tyrosine kinase of the non-receptor type, involved in interleukin-3 and probably interleukin-23 signal transduction (By similarity). Plays a role in leptin signaling and control of body weight.CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.SUBUNIT STRUCTURE: Interacts with IL23R, SKB1 and STAM2 (By similarity). Interacts with SIRPA and SH2B1. SUBCELLULAR LOCATION: Endomembrane system; Peripheral membrane protein By similarity. Note: Wholly intracellular, possibly membrane associated (By similarity).DOMAIN: Possesses two phosphotransferase domains. The second one probably contains the catalytic domain (By similarity), while the presence of slight differences suggest a different role for domain 1.PTM: Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813.SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.Contains 1 FERM domain.Contains 1 protein kinase domain.Contains 1 SH2 domain. View All» Product Name: Anti-JAK2 View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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