货号：06-1330

品牌：Merck Millipore

规格：EA

目录价：￥3468.00

市场价格：￥2947.80

会员价格：￥2774.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PBX1 Antibody | 06-1330 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes PBX1 at the N-terminus. View All» Molecular Weight: ~39 and ~53 kDa observed. Due to alternative splicing PBX1 is observed with two isoforms, Pbx1a and 1b, that are divergent in sequence at the carboxy terminus. View All» Epitope: N-terminus View All» Immunogen: KLH-conjugated linear peptide corresponding to the N-terminus of human PBX1. View All» Background Information: Pre-B-cell leukemia transcription factor 1 (PBX1) is a TALE-class homeodomain transcription factor belonging to the TALE/PBX homeobox family. PBX1 functions as a transcriptional activator of PF4 in complex with MEIS1, facilitating the formation of trimeric transcriptional complexes with Hox proteins. Expression has been observed in human fetal brain which may play a role in the generation of the olfactory bulb interneurons and in mammalian neurogenesis. Mutations in PBX1 have been associated with pre-B-cell acute lymphoblastic leukemia (B-ALL). View All» Species Reactivity:

• Human

• Chimpanzee

• Opossum
  View All» Species Reactivity Note: Demonstrated to react with human. Predicted to react with chimpanzee, opossum, panda, orangutan, platypus, and canine based on 100% sequence homology. View All» Application Notes: Western Blot (SNAP i.d.) Analysis: A 1:500 dilution from a representative lot detected PBX1 on 10 µg of HeLa nuclear extract.Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected PBX1 in NIH/3T3 and HeLa cells. View All» Control: HeLa nuclear extract View All» Quality Assurance: Evaluated by Western Blot in HeLa nuclear extract.Western Blot Analysis: 1:2000 dilution of this antibody detected PBX1 on 10 µg of HeLa nuclear extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P40424 View All» Entrez Gene Number: NP_002576 View All» Gene Symbol:
  • PBX1

  • PRL
    View All» Alternate Names:
    • pre-B-cell leukemia homeobox 1

    • pre-B-cell leukemia transcription factor 1

    • Homeobox protein PRL

    • Pre-B cell leukemia transcription factor-1

    • Homeobox protein PBX1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Binds the sequence 5'-ATCAATCAA-3'. Acts as a transcriptional activator of PF4 in complex with MEIS1. Converted into a potent transcriptional activator by the (1;19) translocation. May have a role in steroidogenesis and, subsequently, sexual development and differentiation. Ref.10SUBUNIT STRUCTURE: Forms a heterodimer with MEIS1 which binds DNA including a cAMP-responsive sequence in CYP17. Also forms heterotrimers with MEIS1 and a number of HOX proteins including HOXA9, HOXD4, HOXD9 and HOXD10. Interacts with PBXIP1. SUBCELLULAR LOCATION: Nucleus Probable. TISSUE SPECIFICTY: Expressed in all tissues except in cells of the B and T lineage.INVOLVEMENT IN DISEASE: Note=A chromosomal aberration involving PBX1 is a cause of pre-B-cell acute lymphoblastic leukemia (B-ALL). Translocation t(1;19)(q23;p13.3) with TCF3. E2A-PBX1 transforms cells by constitutively activating transcription of genes regulated by PBX1 or by other members of the PBX protein family.SEQUENCE SIMILARITIES: Belongs to the TALE/PBX homeobox family.Contains 1 homeobox DNA-binding domain.SEQUENCE CAUTION: The sequence AAA36764.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-PBX1 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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