货号：06-1334

品牌：Merck Millipore

规格：100Ug

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-TAB1 (Thr431) Antibody | 06-1334 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes TAB1 phosphorylated at Thr431. View All» Molecular Weight: ~78 kDa observed. 55 kDa calculated. A higher molecular weight on western blot may be due to glycosylation. An uncharacterized band appears at ~42 and 50 kDa in some lysates. View All» Epitope: Phosphorylated Thr431 View All» Immunogen: KLH-conjugated linear peptide corresponding to human TAB1 phosphorylated at Thr431. View All» Modifications: Phosphorylation View All» Background Information: TAK1 binding protein 1 (TAB1) is thought to activate TAK1 MAPKKK in transforming growth factor-beta (TGF-beta) signaling. TAB1 can also associate with TAK1 to form a unique MAPKKK complex that is thought to activate AP-1 and the NFkappaB signaling pathways. Through conformational changes, TAB1 is also thought to induce p38alpha autophosphorylation. It has been linked to both IL-1alpha and TNFalpha signaling and therefore may also be involved in the inflammatory response. Recent research has found that the TAK1-TAB1 complex may have anti-inflammatory effects by aiding stercurensin in regulating the NFκB-dependent inflammatory pathways. View All» Species Reactivity:

• Mouse

• Human

• Rat

• Horse

• Ox
  View All» Species Reactivity Note: Demonstrated to react with Mouse, Human, and Rat. Predicted to react with Equine and Ox based on 100% sequence homology. View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected TAB1 on 10 µg of L6 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q15750 View All» Entrez Gene Number: NP_006107 View All» Gene Symbol:
  • TAB1

  • MAP3K7IP
    View All» Alternate Names:
    • TGF-beta activated kinase 1/MAP3K7 binding protein 1

    • TAK1-binding protein 1

    • transforming growth factor beta-activated kinase-binding protein 1

    • mitogen-activated protein kinase kinase kinase 7 interacting protein 1

    • Mitogen-activated protein kinase kinase kinase 7-interacting protein 1

    • 3'-Tab1

    • TGF-beta-activated kinase 1-binding protein 1

    • TGF-beta-activated kinase 1 and MAP3K7-binding protein 1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: May be an important signaling intermediate between TGFB receptors and MAP3K7/TAK1. May play an important role in mammalian embryogenesis.SUBUNIT STRUCTURE: Interacts with XIAP and BIRC7. Interacts with TRAF6 and MAP3K7; during IL-1 signaling. Identified in the TRIKA2 complex composed of MAP3K7, TAB1 and TAB2. TISSUE SPECIFICTY: Ubiquitous.PTM: Monoubiquitinated. Deubiquitinated by Y.enterocolitica YopP.SEQUENCE SIMILARITIES: Contains 1 PP2C-like domain. View All» Product Name: Anti-phospho-TAB1 (Thr431) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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