货号：06-1340

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-IKK-epsilon (Ser172) Antibody | 06-1340 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes IKK-epsilon phosphorylated at Ser172. View All» Molecular Weight: ~90 kDa observed View All» Epitope: Phosphorylated Ser172 View All» Immunogen: Linear peptide corresponding to human IKKepsilon phosphorylated at Ser172. View All» Modifications: Phosphorylation View All» Background Information: IKK-epsilon (IkappaB kinase-epsilon) is an IKK-related kinase that is essential for activation of IRF-3 triggered by TLR3 and certain virus’. IKK-epsilon has also been linked to TBK1 that is thought to control phosphorylation of Ser172 in response to LPS, poly(I:C), and IL-1alpha which blocks production of Type 1 interferons during viral and bacterial infection. IKK-epsilon has also been found to negatively affect F actin assembly. IKK-epsilon has been linked to signaling in innate immunity and inflammation. Recently, IKK-epsilon was added to the list of breast cancer oncogenes. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human and Mouse. Predicted to react with Rat based on 100% sequence homology. View All» Control: CD3+CD28 treated and untreated Jurkat cell lysates View All» Quality Assurance: Evaluated by Western Blot in CD3+CD28 treated and untreated Jurkat cell lysates.Western Blot Analysis: 1:1,000 dilution of this antibody detected IKK-epsilon on 10 µg of CD3+CD28 treated and untreated Jurkat cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. View All» UniProt Number: Q14164 View All» Entrez Gene Number: NP_001180251 View All» Gene Symbol:
  • IKBKE

  • IKKE

  • IKKI
    View All» Alternate Names:
    • Inhibitor of nuclear factor kappa-B kinase subunit epsilon

    • I-kappa-B kinase epsilon

    • IKK-E

    • IKK-epsilon

    • IkBKE

    • Inducible I kappa-B kinase

    • IKK-i
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. May play a special role in the immune response. Protects cells against DNA damage-induced cell death.CATALYTIC ACTIVITY: ATP + [I-kappa-B protein] = ADP + [I-kappa-B phosphoprotein].SUBUNIT STRUCTURE: May interact with MAVS/IPS1. Interacts with AZI2. Interacts with SIKE1. Interacts with TICAM1/TRIF, IRF3 and DDX58/RIG-I, interactions are disrupted by the interaction between IKBKE and SIKE1. Interacts with TOPORS; induced by DNA damage. Interacts with CYLD. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Nucleus › PML body. Note: Targeting to PML nuclear bodies upon DNA damage is TOPORS-dependent. TISSUE SPECIFICITY: Highly expressed in spleen followed by thymus, peripheral blood leukocytes, pancreas, placenta. Weakly expressed in lung, kidney, prostate, ovary and colon.PTM: Autophosphorylated. Sumoylation by TOPORS upon DNA damage is required for protection of cells against DNA damage-induced cell death. Desumoylated by SENP1. SEQUENCE SIMILARITIES: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. I-kappa-B kinase subfamily.Contains 1 protein kinase domain.SEQUENCE CAUTION: The sequence BAA09772.2 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-phospho-IKK-epsilon (Ser172) View All» Concentration: 0.09 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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