货号：06-1345

品牌：Merck Millipore

规格：

目录价：￥3262.00

市场价格：￥2772.70

会员价格：￥2609.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NLRP11 Antibody | 06-1345 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NLRP11 at the NACHT domain. View All» Molecular Weight: ~118 kDa observed. An uncharacterized band is observed at ~23 kDa in some lysates. View All» Epitope: NACHT domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human NLRP11 at the NACHT domain. View All» Background Information: NLRP11 is also known as NALP11 and is a member of the NALP family of cytoplasmic proteins. NALPs have been associated with activating caspase-1 using toll-like receptors (TLRs) during the immune response. NLRP11 has been linked to Crohn’s disease susceptibility. View All» Species Reactivity:

• Rat

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a previous lot detected NLRP11 in NIH/3T3 cells. View All» Control: PC12 cell lysate View All» Quality Assurance: Evaluated by Western Blot in PC12 cell lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NLRP11 on 10 µg of PC12 cell lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P59045 View All» Entrez Gene Number: NP_659444 View All» Gene Symbol:
  • NLRP11

  • NALP1

  • PAN10

  • PYPAF6

  • NOD17

  • PYPAF7
    View All» Alternate Names:
    • NLR family, pyrin domain containing 11

    • NACHT, LRR and PYD domains-containing protein 11

    • PAAD- and NACHT-containing protein 10B

    • NACHT, leucine rich repeat and PYD containing 11

    • NACHT, LRR and PYD containing protein 11

    • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 11

    • Nucleotide-binding oligomerization domain protein 17

    • PAAD-and NACHT domain-containing protein 10

    • PAAD- and NACHT-containing protein 10

    • PYRIN-containing APAF1-like protein 6
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» Entrez Gene Summary: Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP11, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Involved in inflammation (Potential).SEQUENCE SIMILARITIES: Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 6 LRR (leucine-rich) repeats.Contains 1 NACHT domain.SEQUENCE CAUTION: The sequence BAC03490.1 differs from that shown. Reason: Erroneous initiation. View All» Product Name: Anti-NLRP11 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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