货号：06-1349

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-NLRP4 Antibody | 06-1349 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes NLRP4 at the NACHT domain. View All» Molecular Weight: ~113 kDa observed. An uncharacterized band appears at ~85 kDa in some lysates. View All» Epitope: NACHT domain View All» Immunogen: KLH-conjugated linear peptide corresponding to human NLRP4 at the NACHT domain. View All» Background Information: NLRP4, also known as NALP4, is a member of the NALP family of cytoplasmic proteins. NALPs have been associated with activating caspase-1 using toll-like receptors (TLRs) during the immune response. NLRP4 may be associated with Peutz-Jeghers syndrome. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Human testis tissue lysate View All» Quality Assurance: Evaluated by Western Blot in human testis tissue lysate.Western Blot Analysis: 1 µg/mL of this antibody detected NLRP4 on 10 µg of human testis tissue lysate. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q96MN2 View All» Entrez Gene Number: NP_604393 View All» Gene Symbol:

• NLRP4

• PAN2

• NALP4

• NLRP4

• CT58

• PYPAF4

• RNH2

• CLR19.5
  View All» Alternate Names:
  • NLR family, pyrin domain containing 4

  • Ribonuclease inhibitor 2

  • PYRIN-containing APAF1-like protein 4

  • PYRIN and NACHT-containing protein 2

  • PAAD and NACHT-containing protein 2

  • NACHT, LRR and PYD domains-containing protein 4

  • NACHT, LRR and PYD containing protein 4

  • NACHT, leucine rich repeat and PYD containing 4

  • nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4

  • Cancer/testis antigen 58
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Summary: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV; MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1; MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: May be involved in inflammation.SEQUENCE SIMILARITIES: Belongs to the NLRP family.Contains 1 DAPIN domain.Contains 8 LRR (leucine-rich) repeats.Contains 1 NACHT domain.SEQUENCE CAUTION: The sequence AAL88672.1 differs from that shown. Reason: Erroneous termination at position 41. Translated as Gln. View All» Product Name: Anti-NLRP4 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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