货号：06-1352

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl Histone H4 (Lys12) Antibody | 06-1352 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H4 acetylated in and around Lys12. View All» Molecular Weight: ~ 14 kDa View All» Epitope: Lys12 View All» Immunogen: Linear peptide corresponding to Arabidopsis thaliana Histone H4 acetylated at and around acetylated Lys12. View All» Modifications: Acetylation View All» Background Information: Histone H4 is one of the 5 main histone proteins involved in the structure of chromatin in eukaryotic cells. Featuring a main globular domain and a long N terminal tail H4 is involved with the structure of the nucleosomes of the 'beads on a string' structure. Acetylation of histone H4 occurs at several different lysine positions in the histone tail and is performed by a family of enzymes known as Histone Acetyl Transferases (HATs). View All» Species Reactivity:

• Human

• Mouse

• Rat

• Drosophila
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. Predicted to react with Arabidopsis thaliana (higher plant) and Drosophila based on 100% sequence homology. View All» Application Notes: Immunocytochemistry Analysis: 1:500 dilution from a representative lot detected Histone H4 in HeLa and A431 cells. View All» Control: Sodium butyrate treated and untreated HeLa cell lysate View All» Quality Assurance: Evaluated by Western Blot in sodium butyrate treated and untreated HeLa cell lysate.Western Blot Analysis: 1:2,000 dilution of this antibody detected Histone H4 on 10 µg of sodium butyrate treated and untreated HeLa cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal in serum with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P59259 View All» Entrez Gene Number: AF325058 View All» Gene Symbol:
  • HIST1H4A

  • H4/J

  • HIST1H4F

  • HIST1H4L

  • H4FN

  • H4FA

  • H4FH

  • HIST1H4H

  • H4F2

  • H4FM

  • H4/A

  • H4FK

  • H4FG

  • HIST2H4

  • H4FB

  • H4/K

  • HIST1H4I

  • H4/N

  • HIST1H4B

  • H4FE

  • H4/M

  • H4/a

  • HIST1H4E

  • HIST4H4

  • HIST2H4A

  • H4FC

  • H4FI

  • H4/H

  • HIST1H4C

  • H4/G

  • HIST1H4K

  • H4FJ

  • H4FD

  • H4/I

  • H4/B

  • H4/D

  • H4/C HIST1H4J

  • HIST1H4D

  • H4/E
    View All» Alternate Names:
    • H4K12Ac

    • Histone H4 (acetyl K12)

    • H4 histone family, member A

    • histone 1, H4a

    • histone cluster 1, H4a
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunocytochemistry
        View All» UniProt Summary: FUNCTION: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.SUBUNIT STRUCTURE: The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.SUBCELLULAR LOCATION: Nucleus By similarity. SEQUENCE SIMILARITIES: Belongs to the histone H4 family. View All» Product Name: Anti-acetyl Histone H4 (Lys12) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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