货号：06-1358

品牌：Merck Millipore

规格：200UL

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl (Lys34) phospho (Ser36) Histone H1 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Histone H1 acetylated at Lys34 and phosphorylated at Ser36. View All» Molecular Weight: ~34 kDa observed View All» Epitope: Acetylated Lys34 and phosphorylated Ser36 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Histone H1 acetylated at Lys34 and phosphorylated at Ser36. View All» Background Information: H1.4 is one of four variants of histone H1 (H1.2-H1.5) that is found in somatic cells. The H1 histones may function as linker proteins binding DNA via their GH domain, and enabling the wrapping of DNA around the core nucleosomal structure formed from the association of H2A, H2B, H3, and H4. In response to various stimuli, histones undergo a number of post-translational modifications (PTM) including acetylation, phoshorylation, and methylation. Previous studies have suggested that H1.4 may be phosphorylated during mitosis and interphase resulting in increased transcription of target genes by RNA polymerase I and II, and therefore this PTM on H1.4 may have implications for cell growth. H1.4 may also undergo acetylation of its N-terminal lysine residues. Often, it is the pattern of different modifications on several histone residues that alter chromatin and affect gene expression, rather than modification of single residues. View All» Species Reactivity:

• Bovine

• Human
  View All» Species Reactivity Note: Demonstrated to react with Bovine and Human. Predicted to react with Canine and Rhesus macaque based on 100% sequence homology. Other homologies: Mouse and Rat (90% sequence homology). View All» Application Notes: Dot Blot Specificity Analysis: Unmodified and various modified Histone peptides (see Table) were probed with acetyl (Lys34) phospho (Ser36) Histone H1. View All» Control: Calf thymus histone extract View All» Quality Assurance: Evaluated by Western Blot in calf thymus histone extract.Western Blot Analysis: A 1:37 dilution of this antibody detected Histone H1 on 10 µg of calf thymus histone extract. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P10412 View All» Entrez Gene Number: NP_005312 View All» Gene Symbol:
  • HIST1H1E

  • H1F4
    View All» Alternate Names:
    • Histone H1.4

    • Histone H1b
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Dot Blot
        View All» Product Name: Anti-acetyl (Lys34) phospho (Ser36) Histone H1 View All» Concentration: 0.11 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µL View All» Format: Affinity Purified View All» Host: Rabbit View All»
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