货号：06-1364

品牌：Merck Millipore

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目录价：￥3789.00

市场价格：￥3220.65

会员价格：￥3031.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SRp30b (SC35) Antibody | 06-1364 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~35 kDa observed. Uncharacterized bands may be observed at ~10, 58, and 78 kDa. View All» Immunogen: Linear peptide corresponding to human SRp30b. View All» Background Information: SRp30b, also known as SC35, and Splicing factor, arginine/serine-rich 2 (SFRS2) is an essential splicing factor. This protein is encoded by the SFRS2 gene and is a member of the splicing factor SR family. SRp30b is involved in pre-mRNA splicing and is found in bodies in the nucleus that are highly enriched in poly(A) RNA. These nuclear bodies are referred to as speckles, SC 35 domains, or splicing factor compartments (SFCs). The purpose of these bodies is not completely characterized. Speckles correspond largely to, if not entirely to, ultra structures called inter-chromatin granule clusters (IGCs). SRp30b is required for pre-mRNA splicing events and is highly involved in spliceosomal interaction and assembly. This SR protein is necessary for assembly of the ATP-dependent splicing complex. It is also necessary for the ATP-dependent communication between pre-mRNA and U1 and U2 snRNPs. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Application Notes: Western Blot Analysis: A 1:500 dilution of a representative lot of this antibody detected SRp30b in 10 µg of HeLa cell lysate.Immunoprecipitation Analysis: A representative lot of this antibody was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.) View All» Control: NIH/3T3 cells. View All» Quality Assurance: Evaluated by Immunocytochemistry Analysis: A 1:500 dilution of this antibody detected SRp30b in NIH/3T3 cells. View All» Purification Method: Protein A View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q01130 View All» Entrez Gene Number: NP_001182356 View All» Gene Symbol:

• SC-35

• PR264

• SFRS2

• SC35

• SRp30b

• SFRS2A

• Protein PR2643

• SRSF2
  View All» Alternate Names:
  • serine/arginine-rich splicing factor 2

  • Splicing factor SC35

  • Splicing component, 35 kDa

  • splicing factor, arginine/serine-rich 2

  • SR splicing factor 2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. Two transcript variants encoding the same protein and one non-coding transcript variant have been found for this gene. In addition, a pseudogene of this gene has been found on chromosome 11. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Necessary for the splicing of pre-mRNA. It is required for formation of the earliest ATP-dependent splicing complex and interacts with spliceosomal components bound to both the 5'- and 3'-splice sites during spliceosome assembly. It also is required for ATP-dependent interactions of both U1 and U2 snRNPs with pre-mRNA. Interacts with other spliceosomal components, via the RS domains, to form a bridge between the 5'- and 3'-splice site binding components, U1 snRNP and U2AF. Binds to purine-rich RNA sequences, either 5'-AGSAGAGTA-3' (S=C or G) or 5'-GTTCGAGTA-3'. Can bind to beta-globin mRNA and commit it to the splicing pathway.SUBUNIT STRUCTURE: In vitro, self-associates and binds SRSF1/SFRS1 (ASF/SF2), SNRNP70 and U2AF1 but not U2AF2. Binds SFRS12. Interacts with CCNL1 and CCNL2. Interacts with SRSF2IP/SFRS2IP. Interacts with ZRSR2/U2AF1-RS2. SUBCELLULAR LOCATION: Nucleus. PTM: Extensively phosphorylated on serine residues in the RS domain. SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.Contains 1 RRM (RNA recognition motif) domain. View All» Product Name: Anti-SRp30b (SC35) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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