货号：06-1367

品牌：Merck Millipore

规格：100UL

目录价：￥4899.00

市场价格：￥4164.15

会员价格：￥3919.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SRp75 Antibody | 06-1367 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Molecular Weight: ~ 62 kDa observed View All» Immunogen: KLH-conjugated linear peptide corresponding to human SRp75. View All» Background Information: SRp75, also known as Serine/arginine-rich splicing factor 4, is an essential splicing factor that is a member of the SR family of proteins. This protein is a component of the pre-mRNA splicing complex and is believed to play a role in alternative splice site selection. Consistent with this excess levels of SRp75 have been shown to play a role in alternative splicing of CD45. SRp75 is normally found in the nucleus and is known to be hyperphosphorylated at serine residues in its RS domain. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Demonstrated to react with human, mouse, and rat. View All» Application Notes: Immunoprecipitation Analysis: A reprentative lot of this antibody was used by an independent laboratory in IP. (Jiang, K., et al. (2009). Endocrinology. 150(5):2087-2097.) View All» Control: L6 cell lysate View All» Quality Assurance: Evaluated by Western Blot in L6 cell lysate.Western Blot Analysis: 1:500 dilution of this antibody detected SRp75 on 10 µg of L6 cell lysate. View All» Purification Method: Protein A View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q08170 View All» Entrez Gene Number: NP_005617 View All» Gene Symbol:
  • SRP001LB

  • SRP75

  • SFRS4

  • SRSF4
    View All» Alternate Names:
    • serine/arginine-rich splicing factor 4

    • splicing factor, arginine/serine-rich 4

    • SR splicing factor 4

    • Pre-mRNA-splicing factor SRP75
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the arginine/serine-rich splicing factor family. The encoded protein likely functions in mRNA processing. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: A probable role in alternative splice site selection during pre-mRNA splicing.SUBUNIT STRUCTURE: Found in a pre-mRNA splicing complex with SRSF4/SFRS4, SRSF5/SFRS5, SNRNP70, SNRPA1, SRRM1 and SRRM2. Interacts with PNN. SUBCELLULAR LOCATION: Nucleus speckle PTM: Extensively phosphorylated on serine residues in the RS domain. SEQUENCE SIMILARITIES: Belongs to the splicing factor SR family.Contains 2 RRM (RNA recognition motif) domains. View All» Product Name: Anti-SRp75 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Purified View All» Host: Rabbit View All»
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