货号：06-1374

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho MRE11 (Thr636) Antibody | 06-1374 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes MRE11 phosphorylated at Thr636. View All» Molecular Weight: ~85 kDa observed View All» Epitope: Phosphorylated Thr636 View All» Immunogen: KLH-conjugated linear peptide corresponding to human MRE11 phosphorylated at Thr636. View All» Modifications: Phosphorylation View All» Background Information: MRE11 is is a nuclear protein involved the DNA damge repair and recombination. This protein is part of the MRN complex composed of three main components: Mre11, Rad50, and Nbs1/Xrs2. This protein complex is involved in signaling pathways that lead to both checkpoint activation and DNA repair. Mutations and defects in expression of this protein can lead to genomic instability, telomere shortening, aberrant meiosis and hypersensitivity to DNA damage. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with human. View All» Control: Anisomycin untreated and treated HEK293 cell lysates View All» Quality Assurance: Evaluated by Western Blot in anisomycin untreated and treated HEK293 cell lysates.Western Blot Analysis: 1 µg/mL of this antibody detected MRE11 on 10 µg of anisomycin untreated and treated HEK293 cell lysates. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P49959 View All» Entrez Gene Number: NP_005581 View All» Gene Symbol:

• MRE11A

• MRE11

• MRE11B

• ATLD

• HNGS1
  View All» Alternate Names:
  • MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

  • meiotic recombination (S. cerevisiae) 11 homolog A

  • double-strand break repair protein MRE11A

  • Meiotic recombination 11 homolog A

  • Meiotic recombination 11 homolog 1

  • DNA recombination and repair protein

  • MRE11 homolog 1

  • endo/exonuclease Mre11

  • MRE11 homolog A

  • AT-like disease
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11A. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11A to prevent nucleolytic degradation past a given point. The complex may also be required for DNA damage signaling via activation of the ATM kinase. In telomeres the MRN complex may modulate t-loop formation.COFACTOR: Manganese (By similarity).SUBUNIT STRUCTURE: Component of the MRN complex composed of two heterodimers RAD50/MRE11A associated with a single NBN. Component of the BASC complex, at least composed of BRCA1, MSH2, MSH6, MLH1, ATM, BLM, RAD50, MRE11A and NBN (By similarity). Interacts with DCLRE1C/Artemis and DCLRE1B/Apollo. SUBCELLULAR LOCATION: Nucleus (By similarity). Note: Localizes to discrete nuclear foci after treatment with genotoxic agents (By similarity).PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. INVOLVEMENT IN DISEASE: Defects in MRE11A are a cause of ataxia telangiectasia-like disorder (ATLD) [MIM:604391]. ATLD is a disease with the same clinical feature than ataxia-telangiectasia but with a somewhat milder clinical course. MISCELLANEOUS: In case of infection by adenovirus E4, the MRN complex is inactivated and degraded by viral oncoproteins, thereby preventing concatenation of viral genomes in infected cells.SEQUENCE SIMILARITIES: Belongs to the MRE11/RAD32 family. View All» Product Name: Anti-phospho MRE11 (Thr636) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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