货号：06-1379

品牌：Merck Millipore

规格：

目录价：￥3908.00

市场价格：￥3321.80

会员价格：￥3126.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PDX1 (rabbit) Antibody | 06-1379 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes the N-terminus of PDX1. View All» Molecular Weight: ~ 39 kDa Observed View All» Epitope: N-terminus View All» Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of mouse PDX1. View All» Isotype: IgG View All» Background Information: Transcription factor PDX1, also known as pancreatic and duodenal homeobox 1, activates expression of the insulin and somatostatin genes. This protein is a key regulator of islet peptide hormone expression and also plays an essential role in pancreatic development. It has been shown to interact with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). This protein also interacts with the methyltransferase SETD7. Mutations in this gene may be involved in several disorders of the pancreas or in diabetes mellitus. View All» Species Reactivity:

• Mouse

• Human
  View All» Species Reactivity Note: Demonstrated to react with human and mouse. View All» Application Notes: Immunohistochemistry Analysis: 1:500 dilution from a representative lot detected PDX1 in normal human pancreas tissue. View All» Control: Mouse pancreatic β T-cell lysate View All» Quality Assurance: Evaluated by Western Blot in mouse pancreatic β T-cell lysate.Western Blot Analysis: 1:1,000 dilution of this antibody detected PDX1 on 10 µg of mouse pancreatic β T-cell lysate. View All» Purification Method: Unpurified View All» Presentation: Unpurified rabbit polyclonal containing 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. View All» UniProt Number: P52946 View All» Entrez Gene Number: NP_032840 View All» Gene Symbol:
  • GSF

  • IDX-1

  • STF-1

  • IUF1

  • PDX-1

  • MODY4

  • IPF1

  • IUF-1

  • IPF-1
    View All» Alternate Names:
    • pancreatic and duodenal homeobox 1

    • pancreatic-duodenal homeobox factor 1

    • somatostatin transcription factor 1

    • insulin promoter factor 1, homeodomain transcription factor

    • Insulin promoter factor 1

    • Somatostatin-transactivating factor 1

    • Insulin upstream factor 1

    • Glucose-sensitive factor

    • Islet/duodenum homeobox-1
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry
        View All» UniProt Summary: FUNCTION: Activates insulin and somatostatin gene transcription. Key regulator of islet peptide hormone expression but also responsible for the development of the pancreas, most probably by determining maturation and differentiation of common pancreatic precursor cells in the developing gut. Binds the DNA sequence 5'-CC[CT]TAATGGG-3'.SUBUNIT STRUCTURE: Interacts with the basic helix-loop-helix domains of TCF3(E47) and NEUROD1 and with HMG-I(Y). Interacts with the methyltransferase SETD7 By similarity. Interacts with SPOP. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Duodenum and pancreas (Langerhans islet beta cells and small subsets of endocrine non-beta-cells, at low levels in acinar cells).DEVELOPMENTAL STAGE: At 8.5 dpc, detected in the gut epithelium from which the pancreatic buds are formed. Transient expression in pancreatic ducts, endocrine and acinar cells. Down-regulated around 10.5 dpc when expression becomes restricted to differentiated beta-cells.DOMAIN: The Antp-type hexapeptide mediates heterodimerization with PBX on a regulatory element of the somatostatin promoter (By Similarity).The homeodomain, which contains the nuclear localization signal, not only mediates DNA-binding, but also acts as a protein-protein interaction domain for TCF3(E47), NEUROD1 and HMG-I(Y) (By Similarity).PTM: Phosphorylated by the SAPK2 pathway at high intracellular glucose concentration.SEQUENCE SIMILARITIES: Belongs to the Antp homeobox family. IPF1/XlHbox-8 subfamily.Contains 1 homeobox DNA-binding domain. View All» Product Name: Anti-PDX1 (rabbit) View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µL View All» Format: Serum View All» Host: Rabbit View All»
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