货号：06-157

品牌：Merck Millipore

规格：200Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-RasGAP Antibody | 06-157 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: GAP View All» Molecular Weight: 120kDa View All» Immunogen: Trp E fusion corresponding to residues 171-448 of human RasGAP View All» Isotype: IgG View All» Species Reactivity:

• Avian

• Human

• Mouse

• Rat
  View All» Quality Assurance: Western Immunoblot Analysis: This antibody, at 0.5 and 2.0 μg/ml, recognized the 120 kDa GAP protein in a RIPA lysate of human Raji lymphocyte cells, lysates of rat L6 myoblasts and mouse Wehi leukemia cells. Immunoprecipitation: 5 μg of this antibody immunoprecipitated the 120kDa GAP protein from a RIPA lysate of human Raji lymphocyte cells. View All» Purification Method: Protein A chromatography View All» Presentation: 200 μg of protein-A purified IgG. Lyophilized from 200 μl of 0.1 M Tris-HCl, 0.15 M NaCl, and 0.05% Na Azide. View All» Storage Conditions: Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -20°C Rehydrate in 200 μl of water. View All» UniProt Number: P20936 View All» Entrez Gene Number: NM_022650 View All» Gene Symbol:
  • RASA1

  • CMAVM

  • CM-AVM

  • RASA

  • PKWS

  • GAP

  • p120GAP

  • RASGAP

  • RasGAP

  • DKFZp434N071
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. View All» UniProt Summary: FUNCTION: SwissProt: P20936 # Inhibitory regulator of the Ras-cyclic AMP pathway. Stimulates the GTPase of normal but not oncogenic Ras p21.SIZE: 1047 amino acids; 116403 Da SUBUNIT: Interacts with SQTSM1.SUBCELLULAR LOCATION: Cytoplasm.PTM: The N-terminus is blocked.DISEASE: SwissProt: P20936 # Mutations in the SH2 domain of RASA seem to be oncogenic and cause basal cell carcinomas. & Defects in RASA1 are the cause of capillary malformation- arteriovenous malformation (CMAVM) [MIM:608354]. CMAVM is a disorder characterized by atypical capillary malformations that are multiple, small, round to oval in shape and pinkish red in color. These capillary malformations are associated with either arteriovenous malformation, arteriovenous fistula, or Parkes Weber syndrome. & Defects in RASA1 are a cause of Parkes Weber syndrome (PKWS) [MIM:608355]. PKWS is a disorder characterized by a cutaneous flush with underlying multiple micro-arteriovenous fistulas, in association with soft tissue and skeletal hypertrophy of the affected limb.SIMILARITY: SwissProt: P20936 ## Contains 1 C2 domain. & Contains 1 PH domain. & Contains 1 Ras-GAP domain. & Contains 2 SH2 domains. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-RasGAP Antibody | 06-157 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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