货号：06-195

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PI3 Kinase Antibody, p85 | 06-195 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes p85 subunit of PI3 kinase. View All» Molecular Weight: 85 kDa View All» Immunogen: Glutathione-S-Transferase fusion proteins containing 1) the N-terminal SH2 domain of rat PI3 kinase and 2) the full length 85kDa subunit of rat PI3 kinase View All» Isotype: IgG View All» Background Information: PI3 Kinase (Phosphatidylinositol 3-Kinase) is responsible for phosphorylation of the 3 position of the inositol ring of PI(4,5)P2, to generate PI(3,4,5)P3, a potent second messenger required for survival signaling, and insulin action. PI3 Kinase is a heterodimeric complex composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. Tyrosine phosphorylation of growth factor receptors creates docking sites for binding of p85 (through its SH2 domains) on the receptors; p85 brings with it p110, which is then proximal to its phospho-lipid substrate on the membrane. PI3 Kinase is also activated by Ras, and by the β,γ subunits of heterotrimeric G-proteins. PI3 Kinase is inhibitable by wortmannin, a useful tool for the study of the PI3 Kinase signaling pathway. View All» Species Reactivity:

• Human

• Mouse

• Monkey

• Rat
  View All» Control: Positive Control Included: Jurkat cell lysate (12-303) View All» Quality Assurance: routinely evaluated by immunoblot on human Jurkat T cells, lysates from mouse NIH 3T3 fibroblasts, rat L6 myoblasts or EGF-stimulated human A431 cells View All» Purification Method: Unpurified View All» Presentation: Immunoaffinity Purified immunoglobulin in 0.2M Tris, 150mM NaCl, 45mM glycine, 0.05% sodium azide and 5mg/ml BSA before the addition of glycerol to 30% View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: Q63787 View All» Gene Symbol:
  • PIK3R1

  • GRB1

  • PI3K

  • p85-ALPHA
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Brand Family: Upstate View All» Product Name: Anti-PI3 Kinase Antibody, p85 | 06-195 View All» Concentration: Variable View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 125 μL View All» Format: Serum View All» Host: Rabbit View All»
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