货号：06-243

品牌：Merck Millipore

规格：

目录价：￥3639.00

市场价格：￥3093.15

会员价格：￥2911.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-TFIIB (N-Term) Antibody | 06-243 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Detects TFIIB. View All» Molecular Weight: GST-tagged recombinant protein including amino acids 2-159 of TFIIB View All» Epitope: N-Term View All» Immunogen: GST-tagged recombinant protein including amino acids 2-159 of TFIIB View All» Background Information: TFIIB (GTF2B, TF2B, general transcription factor IIB) is a ubiquitously expressed transcription factor. TFIIB is essential for the formation of the RNA Polymerase II initiation complex. It is localized to the nucleus where it forms a complex with both TFIIA and TFIID (DAB complex). There it serves a linker between TFIID and RNA Polymerase II. TFIIB is also known to interact with POU3F2. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human. Mouse and Rat are expected to react as they share 99% homology. View All» Control: HeLa nuclear extract View All» Quality Assurance: Routinely evaluated by Western BlotWestern Blot Analysis: This lot detected TFIIB at 1:500 dilution in HeLa nulear extract lysates via SDS-PAGE and transferred to PVDF (Immobilon-P). View All» Purification Method: Antigen affinity purified View All» Presentation: Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 15mM NaCl, and 0.05% NaN3. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt.Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution. View All» UniProt Number: Q00403 View All» Entrez Gene Number: NP_001505 View All» Gene Symbol:
  • GTF2B

  • TF2B

  • TFIIB
    View All» Alternate Names:
    • Transcription initiation factor IIB

    • General transcription factor IIB

    • RNA polymerase II transcription factor IIB
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes the general transcription factor IIB,one of the ubiquitous factors required for transcription initiation by RNA polymerase II. The protein localizes to the nucleus where it forms a complex (the DAB complex) with transcription factors IID and IIA. Transcription factor IIB serves as a bridge between IID, the factor which initially recognizes the promoter sequence, and RNA polymerase II. View All» UniProt Summary: FUNCTION: General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.Cofactor Binds 1 zinc ion per subunit.SUBUNITS: Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II. Interacts with the transcription elongation factor TCEA2. Interacts with HIV-1 Vpr. Interacts with GPBP1 By similarity.SUBCELLULAR LOCATION: Nucleus. SEQUENCE SIMILARITIES: Belongs to the TFIIB family.Contains 1 TFIIB-type zinc finger. View All» Product Name: Anti-TFIIB, (N-term) View All» Concentration: 1.0 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μL View All» Format: Purified View All» Host: Rabbit View All»
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