货号：06-271

品牌：Merck Millipore

规格：

目录价：￥3615.00

市场价格：￥3072.75

会员价格：￥2892.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ZAP-70 Antibody | 06-271 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: ZAP-70; this antiserum also recognizes bands that migrate below the 66 kDa standard and above ZAP-70. Recognition of these proteins is blocked by preincubating with the immunizing peptide. View All» Molecular Weight: 70 kDa View All» Immunogen: peptide corresponding to residues 326-341 of human ZAP-70 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on modified-RIPA lysate of human Jurkat cells View All» Purification Method: Antiserum View All» Presentation: whole rabbit antiserum View All» Storage Conditions: 3 years at -20°C View All» UniProt Number: P43403 View All» Entrez Gene Number: NM_001079 View All» Gene Symbol:
  • ZAP70

  • ZAP-70

  • TZK

  • STD

  • SRK
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene. View All» UniProt Summary: FUNCTION: SwissProt: P43403 # Associates with the T-cell antigen receptor zeta chain (CD3Z). Plays a role in lymphocyte activation.SIZE: 619 amino acids; 69872 Da SUBUNIT: Interacts with SLA2 when it is phosphorylated. Interacts with CD3Z and with phosphorylated NFAM1. Interacts with CBLB (By similarity). Interacts with CBL and SLA when it is phosphorylated. The association with SLA (or SLA2) and CBL probably leads to its destruction. Interacts with SHB. Interacts with DEF6 (By similarity).TISSUE SPECIFICITY: Expressed in T- and natural killer cells.DOMAIN: SwissProt: P43403 The SH2 domain binds to the phosphorylated tyrosine-based activation motif (TAM) of CD3Z.PTM: Phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation. Tyr-319 phosphorylation is essential for full activity.DISEASE:SwissProt: P43403 # Defects in ZAP70 are the cause of selective T-cell defect (STD) [MIM:176947]. STD is an autosomal recessive form of severe combined immunodeficiency characterized by a selective absence of CD8-type T-cells.SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. & Contains 1 protein kinase domain. & Contains 2 SH2 domains. View All» Brand Family: Upstate View All» Product Name: Anti-ZAP-70 Antibody | 06-271 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 150 µL View All» Format: Serum View All» Host: Rabbit View All»
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