货号：06-291

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-gp130 Antibody | 06-291 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes gp130. View All» Molecular Weight: 130 kDa View All» Immunogen: GST-tagged fusion protein corresponding to residues Recombinant gst-gp130 containing the cytoplasmic domain (amino acids 713-918) of human gp130 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: According to a BLAST search, the immunogen has more than 81% homology to human, mouse, dog and rat. View All» Control: Positive Control Included: 3T3 Cell Lysate (12-305) View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 fibroblasts or human A431 carcinoma cell lysate View All» Purification Method: Protein A purfied View All» Presentation: Immunoaffinity Purified immunoglobulin in 0.014M Tris-glycine, pH 7.6, 0.175M NaCl, 0.07% sodium azide) and 30% glycerol View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P40189 View All» Entrez Gene Number: NM_002184 View All» Gene Symbol:
  • IL6ST

  • CD130

  • IL6R-beta

  • GP130-RAPS

  • GP130

  • gp130

  • CDw130

  • IL-6R-beta
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a signal transducer shared by many cytokines, including interleukin 6 (IL6), ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), and oncostatin M (OSM). This protein functions as a part of the cytokine receptor complex. The activation of this protein is dependent upon the binding of cytokines to their receptors. vIL6, a protein related to IL6 and encoded by the Kaposi sarcoma-associated herpesvirus, can bypass the interleukin 6 receptor (IL6R) and directly activate this protein. Knockout studies in mice suggested a critical role of the gene encoding this protein in regulating myocyte apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been described. View All» UniProt Summary: FUNCTION: SwissProt: P40189 # Signal-transducing molecule. The receptor systems for IL6, LIF, OSM, CNTF, IL11, CTF1 and BSF3 can utilize gp130 for initiating signal transmission. Binds to IL6/IL6R (alpha chain) complex, resulting in the formation of high-affinity IL6 binding sites, and transduces the signal. Does not bind IL6. May have a role in embryonic development (By similarity). The type I OSM receptor is capable of transducing OSM-specific signaling events.SIZE: 918 amino acids; 103523 Da SUBUNIT: Interacts with INPP5D/SHIP1 (By similarity). Forms heterodimers composed of LIPR and IL6ST (type I OSM receptor). Also forms heterodimers composed of OSMR and IL6ST (type II OSM receptor).SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.TISSUE SPECIFICITY: Found in all the tissues and cell lines examined. Expression not restricted to IL6 responsive cells.DOMAIN: SwissProt: P40189 The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell- surface receptor binding. & The box 1 motif is required for JAK interaction and/or activation.PTM: Phosphorylation of Ser-782 down-regulates cell surface expression.DISEASE:SwissProt: P40189 # Isoform 2 is an autoantigen found in rheumatoid arthritis (RA) but it is not specific to patients with RA.SIMILARITY: Belongs to the type I cytokine receptor family. Type 2 subfamily. & Contains 5 fibronectin type-III domains. & Contains 1 Ig-like C2-type (immunoglobulin-like) domain. View All» Brand Family: Upstate View All» Product Name: Anti-gp130 Antibody | 06-291 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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