货号：06-326

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-ATF2 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: ATF2 protein, may cross-react with GST-fusion proteins; no cross-reactivity was observed for either ATF-1 or ATF-3. View All» Molecular Weight: 65kDa View All» Immunogen: GST-fusion protein expressed in E. coli containing residues 95-211 of full length human ATF2 (Activating Transcription Factor-2, also called CRE-BP1) View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on HeLa nuclear extract View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P15336 View All» Entrez Gene Number: NM_001880 View All» Gene Symbol:

• ATF2

• MGC111558

• CREB2

• TREB7

• CRE-BP1

• CREBP1

• HB16
  View All» Components: IP/Immunoblotting: use 2 micrograms to immunoprecipitate ATF-2 from HeLa nuclear extract (catalog #12-309); use 4 microgram/ml to detect by immunoblot View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-responsive element (CRE), an octameric palindrome. The protein forms a homodimer or heterodimer with c-Jun and stimulates CRE-dependent transcription. The protein is also a histone acetyltransferase (HAT) that specifically acetylates histones H2B and H4 in vitro; thus it may represent a class of sequence-specific factors that activate transcription by direct effects on chromatin components. Additional transcript variants have been identified but their biological validity has not been determined. View All» UniProt Summary: FUNCTION: SwissProt: P15336 # Transcriptional activator, probably constitutive, which binds to the cAMP-responsive element (CRE) (consensus: 5'- GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Interaction with JUN redirects JUN to bind to CRES preferentially over the 12-O-tetradecanoylphorbol-13-acetate response elements (TRES) as part of an ATF2-c-Jun complex.SIZE: 487 amino acids; 52277 Da SUBUNIT: Binds DNA as a dimer and can form a homodimer in the absence of DNA. Can form a heterodimer with JUN. Interacts with SMAD3 and SMAD4. Binds through its N-terminal region to UTF1 which acts as a coactivator of ATF2 transcriptional activity.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Abundant expression seen in the brain.PTM: Phosphorylation of Thr-51 and Thr-53 by MAPK14 causes increased transcriptional activity. Also phosphorylated and activated by JNK.SIMILARITY: SwissProt: P15336 ## Belongs to the bZIP family. ATF subfamily. & Contains 1 bZIP domain. & Contains 1 C2H2-type zinc finger. View All» Brand Family: Upstate View All» Product Name: Anti-ATF2 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Sheep View All»
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