货号：06-411

品牌：Merck Millipore

规格：

目录价：￥3393.00

市场价格：￥2884.05

会员价格：￥2714.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-PKA Antibody, RII Subunits | 06-411 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: RIIα and β subunits View All» Molecular Weight: 51/54kDa View All» Immunogen: Recombinant RII subunits of mouse cAMP-dependent protein kinase expressed in E. coli View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on mouse 3T3/A31 cells View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P13861 View All» Entrez Gene Number: NM_004157, NM_002736 View All» Gene Symbol:
  • PRKAR2A

  • MGC3606

  • PKR2

  • PRKAR2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting

    • Immunocytochemistry
      View All» Entrez Gene Summary: cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. The protein encoded by this gene is one of the regulatory subunits. This subunit can be phosphorylated by the activated catalytic subunit. It may interact with various A-kinase anchoring proteins and determine the subcellular localization of cAMP-dependent protein kinase. This subunit has been shown to regulate protein transport from endosomes to the Golgi apparatus and further to the endoplasmic reticulum (ER). View All» UniProt Summary: FUNCTION: SwissProt: P13861 # Type II regulatory chains mediate membrane association by binding to anchoring proteins, including the MAP2 kinase.SIZE: 404 amino acids; 45518 Da SUBUNIT: The inactive form of the enzyme is composed of two regulatory chains and two catalytic chains. Activation by cAMP produces two active catalytic monomers and a regulatory dimer that binds four cAMP molecules. Interacts with AKAP4 and CBFA2T3.TISSUE SPECIFICITY: Four types of regulatory chains are found: I- alpha, I-beta, II-alpha, and II-beta. Their expression varies among tissues and is in some cases constitutive and in others inducible.PTM: Phosphorylated by the activated catalytic chain.SIMILARITY: SwissProt: P13861 ## Belongs to the cAMP-dependent kinase regulatory chain family. & Contains 2 cyclic nucleotide-binding domains. View All» Brand Family: Upstate View All» Product Name: Anti-PKA Antibody, RII Subunits | 06-411 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 500 µg View All» Format: Purified View All» Host: Goat View All»
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