货号：06-457

品牌：Merck Millipore

规格：

目录价：￥3522.00

市场价格：￥2993.70

会员价格：￥2817.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Fms/CSF-1 R Antibody, extracellular domain | 06-457 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: extracellular domain of human c-fms gene product (CSF-1 or M-CSF receptor) View All» Molecular Weight: Observed molecular weight at ~220 kDa, theoretical molecular weight at 150-165 kDa. Lower molecular weight degradation products may also be detected. View All» Immunogen: RAB9 cells expressing the first 548 amino acids of human Fms encoded in a pLXSH retroviral vector View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on 3T3/Fms cell lysates View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine pH 7.4, 0.15M NaCl with 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P07333 View All» Entrez Gene Number: NM_005211 View All» Gene Symbol:

• CSF1R

• C-FMS

• CSFR

• FIM2

• CSF-1-R

• c-fms

• CD115

• FMS

• CSF-1R
  View All» Alternate Names: CSF-1R View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The protein encoded by this gene is the receptor for colony stimulating factor 1, a cytokine which controls the production, differentiation, and function of macrophages. This receptor mediates most if not all of the biological effects of this cytokine. Ligand binding activates the receptor kinase through a process of oligomerization and transphosphorylation. The encoded protein is a tyrosine kinase transmembrane receptor and member of the CSF1/PDGF receptor family of tyrosine-protein kinases. Mutations in this gene have been associated with a predisposition to myeloid malignancy. The first intron of this gene contains a transcriptionally inactive ribosomal protein L7 processed pseudogene oriented in the opposite direction. View All» UniProt Summary: FUNCTION: SwissProt: P07333 # This protein is the receptor for CSF-1, it is a protein tyrosine-kinase transmembrane receptor.SIZE: 972 amino acids; 107984 Da SUBUNIT: Interacts with INPPL1/SHIP2 and THOC5 (By similarity).SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Expressed in bone marrow and in differentiated blood mononuclear cells.SIMILARITY: SwissProt: P07333 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. & Contains 5 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-Fms/CSF-1 R Antibody, extracellular domain | 06-457 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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