货号：06-465

品牌：Merck Millipore

规格：EA

目录价：￥3372.00

市场价格：￥2866.20

会员价格：￥2697.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Abl SH2 Domain Antibody | 06-465 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Product Overview: The amount of c-Abl tends to be low in many cell lines and c-Abl was not detected using RIPA lysates from human Jurkat, Raj, Hut lymphoid cell lines, or murine Wehi myeloid cell line View All» Specificity: human p210bcr-abl, p140c-Abl, as well as viral p160gag-abl View All» Molecular Weight: 140kDa View All» Immunogen: Recombinant protein containing Glutathione S-transferase fused to the SH2 domain of Abl View All» Isotype: IgG View All» Species Reactivity:

• Avian

• Bovine

• Human

• Mouse

• Pig

• Rabbit
  View All» Quality Assurance: routinely evaluated by immunoblot on human K562 leukemia cells View All» Purification Method: Ammonium sulfate precipitation View All» Presentation: 0.1M Tris-glycine buffer, pH 7.4 View All» Storage Conditions: 1 year at -20°C View All» UniProt Number: P00519 View All» Entrez Gene Number: NM_009594 View All» Gene Symbol:
  • ABL1

  • v-abl

  • JTK7

  • p150

  • c-ABL

  • bcr/abl

  • ABL
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The ABL1 protooncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response. Activity of c-Abl protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR (MIM:151410) and ABL1 genes present in many cases of chronic myelogeneous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2-11. View All» UniProt Summary: FUNCTION: SwissProt: P00519 # Regulates cytoskeleton remodeling during cell differentiation, cell division and cell adhesion. Localizes to dynamic actin structures, and phosphorylates CRK and CRKL, DOK1, and other proteins controlling cytoskeleton dynamics. Regulates DNA repair potentially by activating the proapoptotic pathway when the DNA damage is too severe to be repaired.COFACTOR: Magnesium or manganese.SIZE: 1130 amino acids; 122873 Da SUBUNIT: Interacts with SORBS1 following insulin stimulation. Found in a trimolecular complex containing CDK5 and CABLES1. Interacts with CABLES1 and PSTPIP1. Interacts with ZDHHC16 (By similarity). Interacts with INPPL1/SHIP2.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=The myristoylated c-ABL protein is reported to be nuclear.TISSUE SPECIFICITY: Widely expressed.PTM: Phosphorylated by PRKDC (By similarity). DNA damage-induced activation of c-Abl requires the function of ATM and Ser-446 phosphorylation. Isoform IB is myristoylated on Gly-2.DISEASE: SwissProt: P00519 # A chromosomal aberration involving ABL1 is a cause of chronic myeloid leukemia (CML) [MIM:608232]. Translocation t(9;22)(q34;q11) with BCR. The translocation produces a BCR-ABL found also in acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).SIMILARITY: SwissProt: P00519 ## Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily. & Contains 1 protein kinase domain. & Contains 1 SH2 domain. & Contains 1 SH3 domain. View All» Brand Family: Upstate View All» Product Name: Anti-Abl SH2 Domain Antibody | 06-465 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 250 µg View All» Format: Purified View All» Host: Rabbit View All»
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