货号：06-479

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DNase I Antibody | 06-479 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: DNase I View All» Molecular Weight: 33kDa View All» Immunogen: Purified bovine pancreatic Deoxy-ribonuclease (DNase I) View All» Isotype: IgG View All» Species Reactivity: Bovine View All» Quality Assurance: routinely evaluated by immunoblot on purified bovine pancreatic DNase I (Promega Catalog #M6101) View All» Purification Method: Delipidation, salt fractionation and ion-exchange chromatography View All» Presentation: PBS, pH 7.2 with 0.01% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P24855 View All» Entrez Gene Number: NM_174534 View All» Gene Symbol:

• DNASE1

• DRNI

• DNL1

• FLJ38093
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. View All» UniProt Summary: FUNCTION: SwissProt: P24855 # Among other functions, seems to be involved in cell death by apoptosis. Binds specifically to G-actin and blocks actin polymerization (By similarity).COFACTOR: Divalent cations. Prefers calcium or magnesium.SIZE: 282 amino acids; 31434 Da SUBCELLULAR LOCATION: Secreted. Nucleus envelope. Note=Secretory protein, stored in zymogen granules and found in the nuclear envelope.TISSUE SPECIFICITY: Principally in tissues of the digestive system. Highest levels found in urine, but also relatively abundant in semen and saliva.DISEASE:SwissProt: P24855 # DNASE1 phenotypes have been shown to be associated with liver diseases.SIMILARITY: SwissProt: P24855 ## Belongs to the DNase I family. View All» Brand Family: Upstate View All» Product Name: Anti-DNase I Antibody | 06-479 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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