货号：06-520

品牌：Merck Millipore

规格：100Ug

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+/K+ ATPase α-1 Antibody | 06-520 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes the α-1 subunit isoform of Na⁺/K⁺ ATPase. View All» Molecular Weight: 112 kDa View All» Epitope: Cytoplasmic domain View All» Immunogen: GST-tagged ATPase. View All» Isotype: IgG View All» Background Information: Na+/K+ ATPase α-1 is a human gene and functions to maintain Na+ and K+ across the cell membrane which is important for osmoregulation. It is a component of (Na+/K+) ATPase, a transporter that catalyzes the hydrolysis of ATP and transports sodium and potassium ions across the plasma membrane. It also partners with Src and other signaling proteins. Binding of ouabain and other cardiotonic steroids to the (Na+/K+) ATPase activates Src, resulting in the assembly and activation of multiple signaling cascades. Binding of ouabain also induces a positive inotropic effect. Diseases associated with ATPase are Thyrotoxic periodic paralysis and hyperthyroidism. (References: Wikipedia and http://www.bioportfolio.com/gene/476-ATP1A1.html) View All» Species Reactivity:

• Bovine

• Rat

• Human
  View All» Species Reactivity Note: Rat and Human. Expected to cross-react with Rat-100%, Mouse-99%; human, pig, rabbit, monkey-96%. View All» Control: Rat Brain Microsomal Prep. lysate. View All» Quality Assurance: Routinely evaluated by Immunoprecipitation on rat brain microsomal prep. lysate. View All» Purification Method: Protein A purfied View All» Presentation: Purified antibody in buffer containing 0.1M Tris-Glycine (pH7.4) 150mM NaCl and 0.05% NaN3. View All» Storage Conditions: Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. View All» UniProt Number: P05023 View All» Entrez Gene Number: NM_001001586 View All» Gene Symbol:
  • ATP1A1

  • G00-119-711

  • Na

  • +K

  • MGC3285

  • MGC51750
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene belongs to the family of P-type cation transport ATPases, and to the subfamily of Na+/K+ -ATPases. Na+/K+ -ATPase is an integral membrane protein responsible for establishing and maintaining the electrochemical gradients of Na and K ions across the plasma membrane. These gradients are essential for osmoregulation, for sodium-coupled transport of a variety of organic and inorganic molecules, and for electrical excitability of nerve and muscle. This enzyme is composed of two subunits, a large catalytic subunit (alpha) and a smaller glycoprotein subunit (beta). The catalytic subunit of Na+/K+ -ATPase is encoded by multiple genes. This gene encodes an alpha 1 subunit. Alternatively spliced transcript variants encoding different isoforms have been identified. View All» UniProt Summary: FUNCTION: SwissProt: P05023 # This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium ions, providing the energy for active transport of various nutrients.SIZE: 1023 amino acids; 112896 Da SUBUNIT: Composed of three subunits: alpha (catalytic), beta and gamma.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.PTM: Phosphorylation on Tyr-10 modulates pumping activity (By similarity).SIMILARITY: SwissProt: P05023 ## Belongs to the cation transport ATPase (P-type) family. Type IIC subfamily. View All» Brand Family: Upstate View All» Product Name: Anti-Na+/K+ ATPase α-1 Antibody | 06-520 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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