货号：06-548

品牌：Merck Millipore

规格：EA

目录价：￥3190.00

市场价格：￥2711.50

会员价格：￥2552.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SLP 76 Antibody | 06-548 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SLP 76 View All» Molecular Weight: 76kDa View All» Immunogen: Bacterially expressed human GST-SLP 76 fusion protein View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Jurkat cells View All» Purification Method: Protein G chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.5, 150mM NaCl, and 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q13094 View All» Entrez Gene Number: NM_005565 View All» Gene Symbol:
  • LCP2

  • SLP-76

  • SLP76
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunofluorescence

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: SLP-76 was originally identified as a substrate of the ZAP-70 protein tyrosine kinase following T cell receptor (TCR) ligation in the leukemic T cell line Jurkat. The SLP-76 locus has been localized to human chromosome 5q33 and the gene structure has been partially characterized in mice. The human and murine cDNAs both encode 533 amino acid proteins that are 72% identical and comprised of three modular domains. The NH2-terminus contains an acidic region that includes a PEST domain and several tyrosine residues which are phosphorylated following TCR ligation. SLP-76 also contains a central proline-rich domain and a COOH-terminal SH2 domain. A number of additional proteins have been identified that associate with SLP-76 both constitutively and inducibly following receptor ligation, supporting the notion that SLP-76 functions as an adaptor or scaffold protein. Studies using SLP-76 deficient T cell lines or mice have provided strong evidence that SLP-76 plays a positive role in promoting T cell development and activation as well as mast cell and platelet function. View All» UniProt Summary: FUNCTION: SwissProt: Q13094 # Involved in T-cell antigen receptor mediated signaling.SIZE: 533 amino acids; 60188 Da SUBUNIT: Interacts with SLA. Interacts with CBLB (By similarity). Interacts with the adapter proteins GRB2 and FYB. Interacts with SHB. Interacts with PRAM1.SUBCELLULAR LOCATION: Cytoplasm (Probable).TISSUE SPECIFICITY: Highly expressed in spleen, thymus, and peripheral blood leukocytes. Highly expressed also in T-cell and monocytic cell lines, expressed at lower level in B-cell lines. Not detected in fibroblast or neuroblasatoma cell lines.DOMAIN:SwissProt: Q13094 The SH2 domain mediates interaction with SHB.PTM: Phosphorylated after T-cell receptor activation by ZAP-70.SIMILARITY: Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-SLP 76 Antibody | 06-548 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 250 µg View All» Format: Purified View All» Host: Sheep View All»
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