货号：06-549

品牌：Merck Millipore

规格：200Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Myc Tag Antibody | 06-549 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes and is specific for human Myc and recombinant proteins containing the Myc epitope tag. View All» Molecular Weight: Predicted molecular weight for human Myc: 49 kDa. Obeserved molecular weight may vary. View All» Epitope: a.a. 409-420 View All» Immunogen: Synthetic peptide corresponding to residues 409-420 of human Myc (MEQKLISEEDLN). View All» Isotype: IgG View All» Background Information: Epitope tags are useful for the labeling and detection of proteins using immunoblotting, immunoprecipitation and immunostaining techniques. Due to their small size, they are unlikely to affect the tagged protein's biochemical properties. The Myc epitope tag is widely used to detect expression of recombinant proteins in bacteria, yeast, insect and mammalian cell systems. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Other species cross-reactivity not tested. View All» Application Notes: Immunocytochemistry: This antibody is reported to detect Myc-tagged proteins in transfected cells. View All» Control: Positive control for human Myc: widespread expression including A431 cell lysate, ovarian cancer cell lysate, or breast carcinoma tissue. Myc fusion protein expressed in cells. View All» Quality Assurance: Evaluated by Western Blot on Myc-PP2A A subunit transfected NIH/3T3 lysates.Western Blotting: 1:500 dilution of this antibody detected myc-PP2A on 10 μg of Myc-PP2A A subunit transfected NIH/3T3 lysates. View All» Purification Method: Protein A chromatography View All» Presentation: Purified rabbit in buffer containing 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl with 0.05% sodium azide. Frozen solution. View All» Storage Conditions: Stable for 1 year at -20ºC from date of receipt. View All» UniProt Number: P01106 View All» Entrez Gene Number: NM_002467.3 View All» Gene Symbol:

• MYC

• C-MYC

• c-Myc
  View All» Alternate Names:
  • Transcription factor p64

  • avian myelocytomatosis viral oncogene homolog

  • myc proto-oncogene protein

  • v-myc avian myelocytomatosis viral oncogene homolog

  • v-myc myelocytomatosis viral oncogene homolog (avian)
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» Entrez Gene Summary: The protein encoded by this gene is a multifunctional, nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. It functions as a transcription factor that regulates transcription of specific target genes. Mutations, overexpression, rearrangement and translocation of this gene have been associated with a variety of hematopoietic tumors, leukemias and lymphomas, including Burkitt lymphoma. There is evidence to show that alternative translation initiations from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site result in the production of two isoforms with distinct N-termini. The synthesis of non-AUG initiated protein is suppressed in Burkitt's lymphomas, suggesting its importance in the normal function of this gene. View All» UniProt Summary: FUNCTION: SwissProt: P01106 # Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes.SIZE: 439 amino acids; 48804 Da SUBUNIT: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with JARID1A and JARID1B.SUBCELLULAR LOCATION: Nucleus.PTM: Phosphorylated by PRKDC.DISEASE: SwissProt: P01106 # Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. & A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t(8;12)(q24;q22) with BTG1.SIMILARITY: SwissProt: P01106 ## Contains 1 basic helix-loop-helix (bHLH) domain. View All» Brand Family: Upstate View All» Product Name: Anti-Myc Tag Antibody | 06-549 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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