货号：06-588

品牌：Merck Millipore

规格：250UL

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-STAT5A/B Antibody | 06-588 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: STAT5A and B View All» Molecular Weight: 90-95 kDa View All» Immunogen: peptide (CQELQKKAEHQVGEDG), corresponding to amino acids 66-80 of human STAT5 A and B View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat

• Sheep
  View All» Quality Assurance: routinely evaluated by Supershift View All» Purification Method: Antiserum View All» Presentation: whole rabbit antiserum containing 0.05% sodium azide View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P42229 View All» Entrez Gene Number: NM_003152.2 View All» Gene Symbol:
  • STAT5A

  • MGF

  • STAT5
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Electrophoretic Mobility Shift Assay View All» Entrez Gene Summary: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. View All» UniProt Summary: FUNCTION: SwissProt: P42229 # Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.SIZE: 794 amino acids; 90647 Da SUBUNIT: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1 and SOCS7.SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Translocated into the nucleus in response to phosphorylation.PTM: Tyrosine phosphorylated in response to IL-2, IL-3, IL-7, IL- 15, GM-CSF, growth hormone, prolactin, erythropoietin and thrombopoietin. Tyrosine phosphorylation is required for DNA- binding activity and dimerization. Serine phosphorylation is also required for maximal transcriptional activity (By similarity).SIMILARITY: SwissProt: P42229 ## Belongs to the transcription factor STAT family. & Contains 1 SH2 domain. View All» Brand Family: Upstate View All» Product Name: Anti-STAT5A/B Antibody | 06-588 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 250 µL View All» Format: Serum View All» Host: Rabbit View All»
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