货号：06-744

品牌：Merck Millipore

规格：200Ug

目录价：￥3999.00

市场价格：￥3399.15

会员价格：￥3199.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DR4/TRAIL-R1 Antibody | 06-744 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: DR4/TRAIL-R1 View All» Molecular Weight: 57kDa View All» Immunogen: peptide (C-RPAREASPRLRVHK) corresponding to amino acids 77-90 of human DR4/TRAIL-R1 View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from Jurkat cells, A431, HeLa, HFF, Raji, 3T3, CTLL, L-6 or PC-12 cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O00220 View All» Entrez Gene Number: NM_003844 View All» Gene Symbol:
  • TNFRSF10A

  • TRAILR1

  • APO2

  • CD261

  • DR4

  • TRAIL-R1

  • TRAILR-1

  • MGC9365

  • Apo2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. View All» UniProt Summary: FUNCTION: SwissProt: O00220 # Receptor for the cytotoxic ligand TNFSF10/TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF- kappa-B.SIZE: 468 amino acids; 50061 Da SUBUNIT: Can interact with TRADD and RIP.SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein.TISSUE SPECIFICITY: Widely expressed. High levels are found in spleen, peripheral blood leukocytes, small intestine and thymus, but also in K562 erythroleukemia cells, MCF7 breast carcinoma cells and activated T-cells.SIMILARITY: SwissProt: O00220 ## Contains 1 death domain. & Contains 3 TNFR-Cys repeats. View All» Brand Family: Upstate View All» Product Name: Anti-DR4/TRAIL-R1 Antibody | 06-744 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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