货号：06-811

品牌：Merck Millipore

规格：

目录价：￥4622.00

市场价格：￥3928.70

会员价格：￥3697.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Na+ Channel α Antibody, cardiac (III-IV loop) | 06-811 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: sodium channel intracellular III-IV loop View All» Molecular Weight: 220 kDa View All» Isotype: IgG View All» Background Information: Voltage-gated sodium channels in the brain are characterized into three subtypes: brain type I, type II and type III based on function and structure. Antibodies against these subtypes consist of a principle alpha subunit with variable isoforms and two auxiliary subunits termed β1 and β2. View All» Species Reactivity: Vertebrates View All» Application Notes: Western Blot: 0.5-2 μg/mL of this lot detected Na+ Channel (III-IV loop) in 20 μg Rat Brain Microsomal Prep. (Catalog # 12-144).Immunoprecipitation: 1-4 μg of a previous lot immunoprecipitated Na+ Channel (III-IV loop) from 400 μg of Rat Brain Microsomal Prep.Immunocytochemistry: (See photo1) Mouse sciatic nerves stained with cat. # 06-811 at 20 µg/mL. View All» Control: Tested on rat brain microsomal lysate View All» Quality Assurance: routinely evaluated by immunoblot on Rat Brain Microsomal Prep View All» Purification Method: Protein A chromatography View All» Presentation: Purified in PBS with 0.05% NaN3 and 30% Glycerol View All» Storage Conditions: Maintain at -20°C in undiluted aliquots for up to 1 year after date of receipt. View All» UniProt Number: P35498 View All» Entrez Gene Number: NM_006920 View All» Gene Symbol:

• SCN1A

• HBSCI

• Nav1.1

• FEB3

• NAC1

• GEFSP2

• SCN1

• SMEI
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
  • Immunocytochemistry

  • Immunoprecipitation

  • Western Blotting
    View All» Entrez Gene Summary: The vertebrate sodium channel is a voltage-gated ion channel essential for the generation and propagation of action potentials, chiefly in nerve and muscle. Voltage-sensitive sodium channels are heteromeric complexes consisting of a large central pore-forming glycosylated alpha subunit and 2 smaller auxiliary beta subunits. Functional studies have indicated that the transmembrane alpha subunit of the brain sodium channels is sufficient for expression of functional sodium channels (Goldin et al., 1986 [PubMed 2429308]; Isom, 2002 [PubMed 11779698]).[supplied by OMIM] View All» UniProt Summary: FUNCTION: SwissProt: P35498 # Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.SIZE: 2009 amino acids; 228972 Da SUBUNIT: The sodium channel consists of a large polypeptide and 2- 3 smaller ones. This sequence represents a large polypeptide.SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.DOMAIN: SwissProt: P35498 The sequence contains 4 internal repeats, each with 5 hydrophobic segments (S1,S2,S3,S5,S6) and one positively charged segment (S4). Segments S4 are probably the voltage-sensors and are characterized by a series of positively charged amino acids at every third position.DISEASE: SwissProt: P35498 # Defects in SCN1A are the cause of generalized epilepsy with febrile seizures plus type 2 (GEFS+2) [MIM:604233]. This autosomal dominant disorder is characterized by febrile seizures in children and afebrile seizures in adults. Penetrance is incomplete and a large intrafamilial variability of the phenotype is observed. & Defects in SCN1A are a cause of severe myoclonic epilepsy in infancy (SMEI) [MIM:607208]; also called Dravet syndrome. SMEI is a severe form of generalized epilepsy with febrile seizures. It is a rare disorder characterized by normal development before onset, seizures beginning in the first year of life in the form of generalized or unilateral febrile clonic seizures, secondary appearance of myoclonic seizures, and occasionally partial seizures. It is associated with ataxia, slowed psychomotor development, and mental decline. & Defects in SCN1A are the cause of familial hemiplegic migraine 3 (FHM3) [MIM:609634]. FHM3 is an autosomal dominant severe subtype of migraine with aura characterized by some degree of hemiparesis during the attacks. The episodes are associated with variable features of nausea, vomiting, photophobia and phonophobia. Age at onset ranges from 6 to 15 years. Some patients may manifest seizures during infancy. & Defects in SCN1A are the cause of familial febrile convulsions 3 (FEB3) [MIM:604403]; also known as familial febrile seizures 3. Febrile convulsions affect 5-12% of infants and children up to 6 years of age. There is epidemiological evidence that febrile seizures are associated with subsequent afebrile and unprovoked seizures in 2% to 7% of patients. Inheritance pattern is autosomal dominant.SIMILARITY: Belongs to the sodium channel family. & Contains 1 IQ domain. View All» Brand Family: Upstate View All» Product Name: Anti-Na+ Channel α Antibody, cardiac (III-IV loop) | 06-811 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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