货号：06-859

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAPK View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes DAP kinase at approximately 130 kDa and occasionally a related band at 66 kDa (based on competition with peptide immunogen) and a non-specific band at 220 kDa. View All» Molecular Weight: 130kDa View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 710-727 of human DAP kinase [C-RRRRPRLSSTNSSRFPPS] View All» Isotype: IgG View All» Background Information: Death Associated Protein Kinase (DAP kinase) is a Ca²⁺/calmodulin-dependent, cytoskeletal associated protein kinase whose expression is implicated in the sensitivity of cells to apoptotic effects of TNF-a and interferon-g. Deletion of the calmodulin-binding domain resulted in a constitutively active mutant with a more potent cytotoxic effect. In contrast, the catalytically inactive mutant exerted a dominant negative effect, reducing cytotoxicity and protecting cells from interferon-γ induced cell death. DAP Kinase expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlates with high rates of metastasis. View All» Species Reactivity: Human View All» Quality Assurance: Immunoblot Analysis: 1-2 μg/ml of this lot detected DAP kinase in whole cell lysates from SK-N-MC cells. View All» Purification Method: Protein A chromatography View All» Presentation: 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P53355 View All» Entrez Gene Number: NM_004938 View All» Gene Symbol:

• DAPK1

• DAPK

• DKFZp781I035
  View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Death-associated protein kinase 1 is a positive mediator of gamma-interferon induced programmed cell death. DAPK1 encodes a structurally unique 160-kD calmodulin dependent serine-threonine kinase that carries 8 ankyrin repeats and 2 putative P-loop consensus sites. It is a tumor suppressor candidate. View All» UniProt Summary: FUNCTION: SwissProt: P53355 # Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.COFACTOR: Magnesium.SIZE: 1432 amino acids; 160286 Da SUBCELLULAR LOCATION: Cytoplasm. Note=Colocalizes with the actin filament system.SIMILARITY: SwissProt: P53355 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 10 ANK repeats. & Contains 1 death domain. & Contains 1 protein kinase domain. View All» Brand Family: Upstate View All» Product Name: Anti-DAPK View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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