货号：06-864

品牌：Merck Millipore

规格：200Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-FLIP Antibody, CT | 06-864 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: long form of FLIP View All» Molecular Weight: 55kDa View All» Immunogen: peptide corresponding to amino acids 447-464 [NGYMYDWNSRVSAKEKYY] of human FLIP View All» Isotype: IgG View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on Jurkat, A431, Raji, 3T3, CTLL, PC12 or L6 RIPA cell lysates View All» Purification Method: Protein A chromatography View All» Presentation: PBS, pH 7.4, 0.02% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O15519 View All» Entrez Gene Number: NM_003879 View All» Gene Symbol:
  • CFLAR

  • I-FLICE

  • CASP8AP1

  • Casper

  • Usurpin

  • FLIP

  • c-FLIPS

  • FLAME

  • CASH

  • c-FLIPL

  • CLARP

  • USURPIN

  • c-FLIPR

  • c-FLIP

  • MRIT

  • FLAME-1
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: O15519 # Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.SIZE: 480 amino acids; 55344 Da SUBUNIT: TNFRSF6 stimulation triggers recruitment to the death- inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.TISSUE SPECIFICITY: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle.DOMAIN: SwissProt: O15519 The caspase domain lacks the active sites residues involved in catalysis.PTM: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12.SIMILARITY: Belongs to the peptidase C14 family. & Contains 2 DED (death effector) domains. View All» Brand Family: Upstate View All» Product Name: Anti-FLIP Antibody, CT | 06-864 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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