货号：06-875

品牌：Merck Millipore

规格：EA

目录价：询价

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SAP30 Antibody | 06-875 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SAP30 View All» Molecular Weight: 30kDa View All» Immunogen: His-tagged human SAP30 View All» Isotype: IgG View All» Species Reactivity: Human View All» Quality Assurance: routinely evaluated by immunoblot on nuclear extracts from HeLa cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.07M Tris-glycine, pH 7.4, 0.105M NaCl, 0.035% sodium azide with 30% glycerol View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: O75446 View All» Entrez Gene Number: NM_003864 View All» Gene Symbol: SAP30 View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. View All» UniProt Summary: FUNCTION: SwissProt: O75446 # Involved in the functional recruitment of the Sin3- histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N- CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.SIZE: 220 amino acids; 23306 Da SUBUNIT: Interacts with SIN3A, SIN3B, HDAC2 and NCOR1 (By similarity). Component of the histone deacetylase complex that includes at least SIN3A, HDAC1 and HDAC2. Interacts with HDAC1 and HCFC1.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Expressed in all tissues tested with highest levels in pancreas, ovary, PBL, spleen and thymus; lowest levels in brain, placenta, lung and kidney.SIMILARITY: SwissProt: O75446 ## Belongs to the SAP30 family. View All» Brand Family: Upstate View All» Product Name: Anti-SAP30 Antibody | 06-875 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»