货号：06-891

品牌：Merck Millipore

规格：100Ug

目录价：￥6127.00

市场价格：￥5207.95

会员价格：￥4901.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-SMRTe Antibody | 06-891 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: SMRT isoforms View All» Molecular Weight: 270kDa, 180kDa and 80kDa View All» Immunogen: GST fusion-protein corresponding to residues 1146-1349 of human SMRTe View All» Isotype: IgG View All» Background Information: SMRT is 1495 amino acids and contains an 8 amino acid sequence that is not present in SMRTe (SMRT-extended), which contains 2514 amino acids. SMRTe contains an N-terminal sequence spanning over 1,000 amino acids that is not present in SMRT, but that shows significant similarity with N-CoR. SMRTe expression is regulated during cell cycle progression, suggesting a role for SMRTe in the regulation of cycle-specific gene expression in diverse signaling pathways. View All» Species Reactivity:

• Human

• Mouse
  View All» Control: Mouse brain nuclear extract View All» Quality Assurance: routinely evaluated by immunoblot on nuclear fraction from murine brain View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q9Y618 View All» Entrez Gene Number: NM_006312 View All» Gene Symbol:
  • NCOR2

  • SMRTE

  • TRAC-1

  • CTG26

  • SMRTe

  • TNRC14

  • SMRT

  • TRAC1

  • SMAP270

  • SMRTE-tau

  • TRAC

  • N-CoR2
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunocytochemistry

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q9Y618 # Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription.SIZE: 2517 amino acids; 274034 Da SUBUNIT: Interacts with HDAC7 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. The SRMT isoform interacts with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3.SUBCELLULAR LOCATION: Nucleus.TISSUE SPECIFICITY: Ubiquitous. High levels of expression are detected in lung, spleen and brain.DOMAIN: SwissProt: Q9Y618 The N-terminal region contains repression functions that are divided into three independent repression domains (RD1, RD2 and RD3). The C-terminal region contains the nuclear receptor- interacting domains that are divided in two separate interaction domains (ID1 and ID2). & The two interaction domains (ID) contain a conserved sequence referred to as the CORNR box. This motif is required and sufficient to permit binding to unligated TR and RARS. Sequences flanking the CORNR box determine nuclear hormone receptor specificity.SIMILARITY: Belongs to the N-CoR nuclear receptor corepressors family. & Contains 2 SANT domains. View All» Brand Family: Upstate View All» Product Name: Anti-SMRTe Antibody | 06-891 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
      © 金山科研平台是专业的授权总代理区域代理经销平台。
      © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
      © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
      © 本文地址：https://www.16ao.com/thread-134509.htm
      © Merck Millipore代理06-891 Anti-SMRTe Antibody;store at +2℃ to +8℃，产品报价联系微信jinshanbio