货号：06-920

品牌：Merck Millipore

规格：

目录价：￥4068.00

市场价格：￥3457.80

会员价格：￥3254.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Smad3 Antibody | 06-920 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Smad3 View All» Molecular Weight: 50kDa View All» Immunogen: peptide [C-NLSPNPMSPAHNNLD-amide] corresponding to amino acids 206-220 of human Smad3 View All» Isotype: IgG View All» Background Information: Members of the Smad family of signal transduction molecules are components of a critical intracellular pathway that transmits TGF-β signals from the cell surface into the nucleus. Three distinct classes of Smads have been defined: the receptor-regulated Smads (R-Smads), which include Smad1, 2, 3, 5 and 8, the common-mediator Smad (co-Smad), Smad4, and the antagonistic or inhibitory Smads (I-Smads), Smad6 and 7. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses. Following stimulation by TGF-β, Smad2 and Smad3 become phosphorylated at their carboxyl termini (Ser465 and 467 on Smad2; Ser423 and 425 on Smad3) by TGF-β Receptor I. Phosphorylated Smad 2/3 can complex with Smad4, translocate to the nucleus and regulate gene expression. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: HepG2 cell lysate View All» Quality Assurance: routinely evaluated by immunoblot on RIPA lysates from HepG2 cells View All» Purification Method: Protein A chromatography View All» Presentation: 0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30% View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: P84022 View All» Entrez Gene Number: NM_022739 View All» Gene Symbol:
  • SMAD3

  • MADH3

  • JV15-2

  • DKFZp686J10186

  • hSMAD3

  • hMAD-3

  • HSPC193

  • MGC60396

  • HsT17436

  • Mad3

  • DKFZP586N0721
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION: SwissProt: P84022 # Transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinase. SMAD3 is a receptor-regulated SMAD (R-SMAD) (By similarity).SIZE: 425 amino acids; 48081 Da SUBUNIT: Interacts with HGS. Interacts with NEDD4L in response to TGF-beta (By similarity). Interacts with SARA (SMAD anchor for receptor activation); form trimers with another SMAD3 and the co- SMAD SMAD4. Interacts with JUN/FOS, vitamin D receptor, homeobox protein TGIF and TGIF2, PEBP2-alpha C subunit, CREB-binding protein (CBP), p300, SKI, SNON, ATF2, SMURF2, AIP1, DACH1 and TGFB1I1. Part of a complex consisting of AIP1, ACVR2A, ACVR1B and SMAD3. Found in a complex with SMAD2 and TRIM33 upon addition of TGF-beta. Interacts with SMAD2 and TRIM33. Found in a complex with SMAD3, Ran and XPO4. Interacts with XPO4.SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4 (By similarity).DOMAIN: SwissProt: P84022 The MH2 domain is sufficient to carry protein nuclear export.PTM: Phosphorylated on serine by TGF-beta and activin type 1 receptor kinases.DISEASE:SwissProt: P84022 # Defects in SMAD3 may be a cause of colorectal cancer (CRC) [MIM:114500].SIMILARITY: Belongs to the dwarfin/SMAD family. & Contains 1 MH1 (MAD homology 1) domain. & Contains 1 MH2 (MAD homology 2) domain. View All» Brand Family: Upstate View All» Product Name: Anti-Smad3 Antibody | 06-920 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 400 µg View All» Format: Purified View All» Host: Rabbit View All»
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