货号：06-984

品牌：Merck Millipore

规格：200Ug

目录价：￥6742.00

市场价格：￥5730.70

会员价格：￥5393.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Mn-SOD Antibody | 06-984 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes MnSOD, Mr 24 kDa. View All» Molecular Weight: ~24 kDa View All» Immunogen: Recombinant human MnSOD (manganous superoxide dismutase). View All» Isotype: IgG View All» Background Information: Superoxide dismutase (SOD) is an antioxidant enzyme involved in the defense system against reactive oxygen species (ROS). SOD catalyzes the dismutation reaction of superoxide radical anion (O2-) to hydrogen peroxide, which is then catalyzed to innocuous O2 and H2O by glutathione peroxidase and catalase. Several classes of SOD have been identified. These include intracellular copper, zinc SOD (Cu, Zn SOD/SOD1), mitochondrial manganese SOD (Mn SOD/SOD2) and extracellular Cu, Zn SOD (EC SOD/SOD3). The manganese containing 80 kDa tetrameric enzyme SOD2 is located in the mitochondrial matrix in close proximity to a primary endogenous source of superoxide, the mitochondrial respiratory chain. View All» Species Reactivity:

• Human

• Rat

• Mouse

• Bovine
  View All» Species Reactivity Note: Human, mouse, rat and bovine. Not canine (dog). View All» Non-Reactive Species: Canine View All» Application Notes: Immunohistochemistry (Paraffin): 10 μg/mL of a previous lot detected MnSOD in paraffin embedded rat brain tissue sections. View All» Control: L6 cell lysate, rat brain tissue extract. View All» Quality Assurance: Evaluated by western blot on RIPA lysates of MCF-7, A431 or rat L6 RIPA cells.Western Blot Analysis: 0.5-2 μg/mL of this antibody detected MnSOD in RIPA lysates of rat L6 RIPA cells. 1-4 μg/mL of a previous lot detected MnSOD in RIPA lysates of human MCF-7, A431 and rat L6 RIPA cells. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal in buffer containing 70% storage buffer 0.1 M Tris-glycine, pH 7.4, 0.15 M NaCl, 0.05% sodium azide and 30% glycerol. View All» Storage Conditions: Stable for 1 year at 2 to 8ºC from date of receipt. View All» UniProt Number: P04179 View All» Entrez Gene Number: NP_000627 View All» Gene Symbol:
  • SOD2

  • Mn-SOD

  • MNSOD

  • MnSOD

  • IPO-B
    View All» Alternate Names:
    • Mn superoxide dismutase

    • indophenoloxidase B

    • manganese superoxide dismutase

    • manganese-containing superoxide dismutase

    • mangano-superoxide dismutase

    • superoxide dismutase 2, mitochondrial
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Immunohistochemistry

      • Immunohistochemistry (Paraffin)

      • Western Blotting
        View All» Entrez Gene Summary: This gene is a member of the iron/manganese superoxide dismutase family. It encodes a mitochondrial protein that forms a homotetramer and binds one manganese ion per subunit. This protein binds to the superoxide byproducts of oxidative phosphorylation and converts them to hydrogen peroxide and diatomic oxygen. Mutations in this gene have been associated with idiopathic cardiomyopathy (IDC), premature aging, sporadic motor neuron disease, and cancer. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. View All» UniProt Summary: FUNCTION: SwissProt: P04179 # Destroys radicals which are normally produced within the cells and which are toxic to biological systems.COFACTOR: Binds 1 manganese ion per subunit.SIZE: 222 amino acids; 24722 Da SUBUNIT: Homotetramer.SUBCELLULAR LOCATION: Mitochondrion matrix.SIMILARITY:SwissProt: P04179 ## Belongs to the iron/manganese superoxide dismutase family. View All» Brand Family: Upstate View All» Product Name: Anti-Mn-SOD Antibody | 06-984 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 μg View All» Format: Purified View All» Host: Rabbit View All»
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