货号：07-024

品牌：Merck Millipore

规格：200Ug

目录价：￥6588.00

市场价格：￥5599.80

会员价格：￥5270.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-gp91-phox Antibody | 07-024 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Detects gp91-phox, Mr 75 kDa. Depending on the type of lysate, the amount loaded, the gel and the blotting conditions, gp91-phox may run as a sharp band, Mr 75 kDa, or appear as a smear between 75-91 kDa. View All» Molecular Weight: Varies. Depending on the type of lysate, the amount loaded, the gel and the blotting conditions, gp91-phox may run as a sharp band, Mr ~75 kDa, or appear as a smear between 75-91 kDa. View All» Immunogen: KLH-conjugated, synthetic peptide corresponding to amino acids 548-560 of human gp91-phox (KQSISNSESGPRG). The immunizing sequence is identical in mouse, and it shares 11/13 sequence homology in bovine and 10/13 in porcine. View All» Isotype: IgG View All» Background Information: Cytochrome b-245, beta polypeptide (chronic granulomatous disease), also known as CYBB and P91-PHOX, is a human gene encoding a glycoprotein.Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. View All» Species Reactivity: Human View All» Species Reactivity Note: Human. Predicted to cross react with mouse. View All» Application Notes: Immunoprecipitation: Not recommended. View All» Control: Lung tissue, human neutrophil membrane, HL60 membrane and RIPA cell lysate. View All» Quality Assurance: Routinely evaluated by Western Blot on human neutrophil membranes.Western Blot Analysis: 1-4 µg/mL of this lot detected gp91-phox in a HL60 membrane and RIPA cell lysate. A previous lot detected gp91-phox in human neutrophil membranes. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 0.07 M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide and 30% glycerol. Liquid at -20°C. View All» Storage Conditions: Stable for 1 year at -20°C from date of receipt. For maximum recovery of product, centrifuge the vial prior to removing the cap.Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variabillity in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P04839 View All» Entrez Gene Number: NM_000397 View All» Gene Symbol:

• CGD

• CGD91-phox

• EC 1.-.-.-

• GP91-1

• GP91-PHOX

• GP91PHOX

• NOX2

• OTTHUMP00000031915

• gp91-1

• gp91-phox

• p91-PHOX
  View All» Alternate Names:
  • Cytochrome b(558) subunit beta

  • Cytochrome b558 subunit beta

  • Heme-binding membrane glycoprotein gp91phox

  • NADPH oxidase

  • Neutrophil cytochrome b 91 kDa polypeptide

  • Superoxide-generating NADPH oxidase heavy chain subunit

  • chronic granulomatous disease

  • cytochrome b-245 beta polypeptide

  • cytochrome b-245, beta polypeptide

  • p22 phagocyte B-cytochrome
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cell's respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. View All» UniProt Summary: FUNCTION: SwissProt: P04839 # Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. It is the terminal component of a respiratory chain that transfers single electrons from cytoplasmic NADPH across the plasma membrane to molecular oxygen on the exterior. Also functions as a voltage-gated proton channel that mediates the H(+) currents of resting phagocytes. It participates in the regulation of cellular pH and is blocked by zinc.COFACTOR: FAD (Probable).SIZE: 570 amino acids; 65336 Da SUBUNIT: Composed of a heavy chain (beta) and a light chain (alpha).SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.PTM: Glycosylated.DISEASE: SwissProt: P04839 # Defects in CYBB are a cause of X-linked chronic granulomatous disease (X-CGD) [MIM:306400]. X-CGD is characterized by the failure of activated phagocytes to generate superoxide. Patients suffer from life-threatening bacterial/fungal infections. Patients with CYBB dysfunction are generally classified into three groups, namely X91(0) (no expression of the protein); X91(-) (reduced expression) and X91(+) (normal expression).SIMILARITY: SwissProt: P04839 ## Contains 1 ferric oxidoreductase domain. View All» Brand Family: Upstate View All» Product Name: Anti-gp91-phox Antibody | 07-024 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
    © 金山科研平台是专业的授权总代理区域代理经销平台。
    © 如需询价，请加客服QQ：1749072012 、客服微信：jinshanbio，或发送邮件到1749072012@qq.com
    © 平台为生命科学研究相关领域提供一站式耗材试剂仪器解决方案和采购服务，数据资源基于CC协议。
    © 本文地址：https://www.16ao.com/thread-134550.htm
    © Merck Millipore代理07-024 Anti-gp91-phox Antibody;store at -20℃，产品报价联系微信jinshanbio