货号：07-087

品牌：Merck Millipore

规格：

目录价：￥4068.00

市场价格：￥3457.80

会员价格：￥3254.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-mAKAP Antibody | 07-087 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: mAKAP View All» Molecular Weight: 255 and 300kDa View All» Immunogen: His-tagged, recombinant protein corresponding to residues 1666-2319 of human muscle AKAP View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat
  View All» Quality Assurance: routinely evaluated by immunoblot on RIPA cell lysates from L6 cells View All» Purification Method: Protein A purfied View All» Presentation: 200 µg protein A purified rabbit IgG in 200 µL of 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% sodium azide, and 30% glycerol. Frozen solution. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q13023 View All» Entrez Gene Number: NM_004274 View All» Gene Symbol:
  • AKAP6

  • mAKAP

  • ADAP100

  • PRKA6

  • ADAP6

  • AKAP100

  • KIAA0311
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunohistochemistry

    • Immunoprecipitation

    • Western Blotting
      View All» Entrez Gene Summary: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is highly expressed in various brain regions and cardiac and skeletal muscle. It is specifically localized to the sarcoplasmic reticulum and nuclear membrane, and is involved in anchoring PKA to the nuclear membrane or sarcoplasmic reticulum. View All» UniProt Summary: FUNCTION: SwissProt: Q13023 # Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes.SIZE: 2319 amino acids; 256720 Da SUBUNIT: Interacts with RII subunit of PKA, phosphatase 2B (calcineurin) and AKAP79.SUBCELLULAR LOCATION: Sarcoplasmic reticulum. Nucleus membrane. Note=In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs or alternatively splice targeting sequences.TISSUE SPECIFICITY: Highly expressed in cardiac and skeletal muscle, followed by brain.DOMAIN:SwissProt: Q13023 RII-alpha binding site, predicted to form an amphipathic helix, could participate in protein-protein interactions with a complementary surface on the R-subunit dimer.SIMILARITY: Contains 2 spectrin repeats. View All» Brand Family: Upstate View All» Product Name: Anti-mAKAP Antibody | 07-087 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 200 µg View All» Format: Purified View All» Host: Rabbit View All»
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