货号：07-091

品牌：Merck Millipore

规格：100Ug

目录价：￥5053.00

市场价格：￥4295.05

会员价格：￥4042.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-Pin1 Antibody | 07-091 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Pin1 View All» Molecular Weight: 18kDa View All» Immunogen: Full-length His tagged human Pin-1 View All» Isotype: IgG View All» Background Information: Pin1 is a peptidyl-prolyl isomerase (PPI) that targets phosphorylated Ser or Thr residues followed by a Pro (S/T-P). Isomerization of phosphorylated Ser or Thr residues may alter protein confirmation and, subsequently, modify activity. Pin1 is overexpressed in many human breast cancers, and has been shown to modify numerous proteins including p53,NF-κB, c-Jun, cyclin D1, and β-catenin. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Control: 3T3 cell lysate, HeLa cell lysate, MCF-7 cell lysate View All» Quality Assurance: Routinely evaluated by immunoblot on RIPA lysates from mouse 3T3/A31 cells View All» Purification Method: Protein A chromatography View All» Presentation: Presentation: 100 µg of protein A purified rabbit IgG in 100 µL of 0.014 M phosphate buffer, pH 7.6, 0.175 M NaCl, 0.07% Sodium Azide and 30% glycerol. Liquid at -20°C. View All» Storage Conditions: 2 years at -20°C View All» UniProt Number: Q13526 View All» Entrez Gene Number: NM_006221 View All» Gene Symbol:
  • PIN1

  • dod

  • UBL5

  • DOD
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Immunoprecipitation

    • Western Blotting
      View All» UniProt Summary: FUNCTION: SwissProt: Q13526 # Essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Displays a preference for an acidic residue N-terminal to the isomerized proline bond. Catalyzing pSer/Thr-Pro cis/trans isomerizations.SIZE: 163 amino acids; 18243 Da SUBUNIT: Interacts with STIL (By similarity). Interacts with MPHOSPH1.SUBCELLULAR LOCATION: Nucleus.DOMAIN:SwissProt: Q13526 The WW domain is required for the interaction with STIL and MPHOSPH1.PTM: Phosphorylated upon DNA damage, probably by ATM or ATR.SIMILARITY: Contains 1 PpiC domain. & Contains 1 WW domain. View All» Brand Family: Upstate View All» Product Name: Anti-Pin1 Antibody | 07-091 View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 µg View All» Format: Purified View All» Host: Rabbit View All»
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