货号：07-1229

品牌：Merck Millipore

规格：100Ug

目录价：￥4592.00

市场价格：￥3903.20

会员价格：￥3673.60

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-DAPK2 Antibody | 07-1229 View All» Replaces: 07-1229 is a recommended replacement for AB3606. View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Detects a 42 kDa band by western blot, corresponding to DAPK2. Does not cross-react with DAPK1. View All» Molecular Weight: Detects a 42 kDa band by western blot. View All» Immunogen: Peptide corresponding to aa 356-370 (ARRKALHPRRRSSTS) of human DAPK2, which is identical to the sequence of mouse origin. View All» Isotype: IgG View All» Background Information: Death Associated Protein Kinase (DAPK) is a Ca2+/Calmodulin-dependent, cytoskeletal associated protein kinase whose expression is implicated in the sensitivity of cells to apoptotic effects of TNFα and Interferon-γ. Deletion of the Calmodulin-binding domain results in a constitutively active mutant with a more potent cytotoxic effect. In contrast, the catalytically inactive mutant exerts a dominant negative effect, reducing cytotoxicity and protecting cells from Interferon-γ induced cell death. DAPK expression is frequently lost in human carcinomas and B-cell leukemia, and lower levels of expression correlate with high rates of metastasis. View All» Species Reactivity:

• Human

• Mouse

• Rat
  View All» Species Reactivity Note: Human, Mouse and Rat View All» Application Notes: Immunohistochemisty (paraffin): DAPK2 representative staining pattern/morphology in apoptotic bodies in colon cancer. Tissue was pretreated with citrate pH 6, antigen retrieval. A previous lot of this antibody was diluted to 1:100, using IHC-Select® Detection with HRP-DAB.Western Blot: A previous lot of this antibody was tested on multiple lysates. See datasheet. View All» Control: C2C12 cell lysate View All» Quality Assurance: Routinely evaluated by Western Blot on C2C12 lysates. Western Blot Analysis: 1:500-1,1000 dilution of this lot detected DAPK2 on 10 μg of C2C12 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing PBS and 0.02% sodium azide. View All» Storage Conditions: Stable for 6 months at 2-8° C from date of receiept. View All» UniProt Number: Q9UIK4 View All» Entrez Gene Number: NM_014326 View All» Gene Symbol:
  • DAPK2

  • DRP-1

  • MGC119312

  • EC 2.7.11.1
    View All» Alternate Names:
    • DAP kinase

    • DAP- kinase-related protein

    • Death-associated protein kinase
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Overexpression of this gene was shown to induce cell apoptosis. It uses multiple polyadenylation sites. View All» UniProt Summary: FUNCTION: SwissProt: Q9UIK4 # Calcium/calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis.COFACTOR: Magnesium.SIZE: 370 amino acids; 42898 Da SUBUNIT: Homodimer. Homodimerization is required for apoptotic function and is inhibited by autophosphorylation at Ser-318.SUBCELLULAR LOCATION: Cytoplasm.TISSUE SPECIFICITY: Ubiquitously expressed in all tissue types examined. High levels in heart, lung and skeletal muscle.SIMILARITY: SwissProt: Q9UIK4 ## Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. DAP kinase subfamily. & Contains 1 protein kinase domain. ... View All» Product Name: Anti-DAPK2 Antibody | 07-1229 View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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