货号：07-1230

品牌：Merck Millipore

规格：EA

目录价：￥3550.00

市场价格：￥3017.50

会员价格：￥2840.00

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-GADD45α Antibody | 07-1230 View All» Replaces: 07-1230 is a recommended replacement for AB3863 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Trade Name: Upstate (Millipore) View All» Specificity: Recognizes GADD45α, also known as Growth Arrest and DNA-Damage-inducible, alpha. View All» Molecular Weight: 18 kDa (monomer) and 27-30 kDa (homodimer) View All» Epitope: N-terminus View All» Immunogen: Synthetic peptide corresponding to the N-terminus of human GADD45α (MTLEEFSAGEQKTERMDKVGDALEE). View All» Isotype: IgG View All» Species Reactivity:

• Human

• Rat

• Mouse
  View All» Species Reactivity Note: Human, Rat and Mouse View All» Application Notes: Immunohistochemistry(paraffin): Representative testing from a previous lot. Optimal Staining of GADD45 Polyclonal Antibody: Placenta GADD45 staining on human placental lining cells, pretreated with citrate buffer, pH 6.0. A previous lot of this antibody was diluted to 1 µg/mL, using IHC-Select® detection with HRP-DAB. Immunoreactivity is seen as membrane staining. View All» Control: HEK293, Lung tissue, Kidney tissue View All» Quality Assurance: Routinely evaluated by Western Blot on HEK293 lysates. Western Blot Analysis: 1:500 dilution of this lot detected GADD45A on 10 μg of HEK293 lysates. View All» Purification Method: Protein A purfied View All» Presentation: Purified rabbit polyclonal IgG in buffer containing 0.02 M Phosphate with 0.15 M NaCl, pH 7.6 and 0.1% sodium azide as a preservative. View All» Storage Conditions: Stable at 2-8 °C in undiluted aliquots for up to 6 months from date of receipt. View All» UniProt Number: P24522 View All» Entrez Gene Number: NM_001924 View All» Gene Symbol:
  • GADD45A

  • DDIT1

  • GADD45

  • DDIT-1
    View All» Alternate Names:
    • DNA-damage-inducible transcript

    • Growth arrest and DNA-damage-inducible protein GADD45 alpha

    • Growth arrest and DNA-damage-inducible 45 alpha

    • Growth arrest and DNA-damage-inducible, alpha
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. [provided by RefSeq]. View All» UniProt Summary: FUNCTION: Binds to proliferating cell nuclear antigen. Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase.SUBUNIT: Interacts with GADD45GIP1.INDUCTION: By UV radiation, X-rays, growth arrest and alkylatingagents. The induction is mediate by some kinase(s) other than PKC.DISEASE: Induction of GADD45 in ataxia telangiectasia cells is abnormal.SIMILARITY: Belongs to the GADD45 family. View All» Brand Family: Upstate View All» Product Name: Anti-GADD45α Antibody | 07-1230 View All» Concentration: 0.95 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Purified View All» Host: Rabbit View All»
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