货号：07-1238

品牌：Merck Millipore

规格：100UL

目录价：￥4438.00

市场价格：￥3772.30

会员价格：￥3550.40

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-MARCKS (Ser152/156) Antibody | 07-1238 View All» Replaces: 07-1238 is a recommended replacement for AB5879 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: MARCKS, phosphoSer152/156. View All» Molecular Weight: ~80 kDa View All» Epitope: phosphoSer 152/156 View All» Immunogen: Synthetic peptide corresponding to amino acids surrounding the phosphoSer152/156 of rat MARCKS. View All» Modifications: Phosphorylation View All» Isotype: IgG View All» Background Information: Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) is a widely expressed substrate of PKC. MARCKS is essential in neuronal development, as mice deficient in it die shortly after birth. Through its basic effector region, MARCKS associates with acidic membrane phospholipids, actin filaments, and calmodulin. Poly (ADP-ribose) also binds the basic effector region, blocking calmodulin binding, membrane association, and phosphorylation by PKC, suggesting that MARCKS may be an effector of the DNA-damage signal transduced by poly (ADP-ribose). View All» Species Reactivity:

• Rat

• Human

• Mouse
  View All» Species Reactivity Note: Human, mouse and rat. View All» Application Notes: Immunohistochemistry(paraffin):Representative images from a previous lot.Optimal Staining of MARCKS With Citrate pH 6.0 Epitope Retrieval: Rat PlacentaOptimal working dilutions must be determined by the end user. View All» Control: A431 Cell Lysate View All» Quality Assurance: Routinely evaluated by Western Blot on EGF treated A431 lysates.Western Blot Analysis: 1:500 dilution of this lot detected phosphorylated MARCKS on 10 μg of EGF treated A431 lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified rabbit polyclonal IgG in 10 mM Hepes, pH 7.5, with 150 mM NaCl, 100 µg/mL BSA and 50% glycerol. View All» Storage Conditions: Stable at -20°C in undiluted for up to 6 months from date of receipt. Avoid repeated freeze/thaw cycles. Do not store in a self-defrosting freezer. Handling Recommendations: Upon first thaw, and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage. View All» UniProt Number: P29966 View All» Entrez Gene Number: NM_002356.5 View All» Gene Symbol:
  • MARCKS

  • MACS

  • 80K-L

  • PRKCSL

  • FLJ14368

  • phosphomyristin

  • MRACKS

  • PKCSL

  • FLJ90045
    View All» Alternate Names:
    • Myristoylated alanine-rich C-kinase substrate

    • Protein kinase C substrate, 80 kDa protein, light chain
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
      • Western Blotting

      • Immunohistochemistry (Paraffin)
        View All» Entrez Gene Summary: The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. View All» UniProt Summary: FUNCTION: SwissProt: P29966 # MARCKS is the most prominent cellular substrate for protein kinase C. This protein binds calmodulin, actin, and synapsin. MARCKS is a filamentous (F) actin cross-linking protein.SIZE: 332 amino acids; 31555 Da PTM: Phosphorylation by PKC displaces MARCKS from the membrane. It also inhibits the F-actin cross-linking activity.SIMILARITY: SwissProt: P29966 ## Belongs to the MARCKS family. View All» Product Name: Anti-phospho-MARCKS (Ser152/156) Antibody | 07-1238 View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μL View All» Target / Localization: Soma View All» Format: Affinity Purified View All» Host: Rabbit View All»
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