货号：07-1317

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Leptin receptor (Tyr1077) Antibody | 07-1317 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes phosphorylated Leptin receptor at Tyr1077. View All» Molecular Weight: Expected 132 kDa, observed 65 kDa View All» Epitope: Tyr1077 View All» Immunogen: KLH-conjugated linear peptide corresponding to mouse phosphoylated Leptin receptor at and around Tyr1077. View All» Modifications: Phosphorylation View All» Background Information: Leptin (LEP; MIM 164160), an adipocyte-specific hormone that regulates adipose-tissue mass through hypothalamic effects on satiety and energy expenditure, acts through the leptin receptor (LEPR), a single-transmembrane-domain receptor of the cytokine receptor family. View All» Species Reactivity:

• Human

• Mouse
  View All» Species Reactivity Note: Reacts with human. Predicted to react with mouse based on sequence homology. View All» Control: Leptin Receptor IP lysate. View All» Quality Assurance: Evaluated by Western Blot in Leptin Receptor IP lysate. (See below)Western Blot Analysis: 1:500 dilution of this antibody detected Leptin Receptor phosphorylated at Tyr1077 in Leptin Receptor IP lysate. View All» Purification Method: Affinity Purfied View All» Presentation: Affinity purified rabbit serum in 0.1M Tris-Glycine (pH7.4) 150mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Maintain refrigerated at 2-8°C for up to 12 months. View All» UniProt Number: Q8TCD6 View All» Entrez Gene Number: AAC52421.1 View All» Gene Symbol:
  • CD295

  • DB

  • HuB219

  • LEP-R

  • OB-R

  • OBR

  • OTTHUMP00000010693

  • OTTHUMP00000010694
    View All» Alternate Names:
    • CD295 antigen

    • OB receptor

    • leptin receptor
      View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» UniProt Summary: FUNCTION:Receptor for obesity factor (leptin). On ligand binding, mediates signaling through JAK2/STAT3. Involved in the regulation of fat metabolism and, in a hematopoietic pathway, required for normal lymphopoiesis. May play a role in reproduction. Can also mediate the ERK/FOS signaling pathway By similarity.SUBUNIT STRUCTURE: On leptin stimulation, homodimerizes. The phosphorylated receptor binds a number of SH2 domain-containing proteins such as STAT3, PTPN11, and SOCS3 By similarity. Interaction with SOCS3 inhibits LRb signaling By similarity.SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.Isoform E: Secreted Probable. TISSUE SPECIFICITY: Isoform A is expressed in fetal liver and in hematopoietic tissues and choroid plexus. In adults highest expression in heart, liver, small intestine, prostate and ovary. Low level in lung and kidney. Isoform B is highly expressed in hypothalamus.DOMAIN: The cytoplasmic domain may be essential for intracellular signal transduction by activation of JAK tyrosine kinase and STATs.The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.The box 1 motif is required for JAK interaction and/or activation.PTM:On ligand binding, phosphorylated on two conserved C-terminal tyrosine residues (isoform B only) by JAK2. Tyr-986 is required for complete binding and activation of PTPN11, ERK/FOS activation and, for interaction with SOCS3 By similarity. Phosphorylation on Tyr-1141 is required for STAT3 binding/activation.SEQUENCE SIMILARITIES: Belongs to the type I cytokine receptor family. Type 2 subfamily.Contains 4 fibronectin type-III domains.Contains 1 Ig-like (immunoglobulin-like) domain. View All» Product Name: Anti-phospho-Leptin receptor (Tyr1077 View All» Concentration: 0.86 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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