货号：07-1331

品牌：Merck Millipore

规格：

目录价：￥3346.00

市场价格：￥2844.10

会员价格：￥2676.80

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-Rictor (Ser1219) Antibody | 07-1331 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes Rictor phosphorylated at Ser1219. View All» Molecular Weight: ~225 kDa observed. The band at ~27 kDa is background reactivity to the light chain from the Rictor antibody. View All» Epitope: Phosphorylated Ser1219 View All» Immunogen: KLH-conjugated linear peptide corresponding to human Rictor phosphorylated at Ser1219. View All» Modifications: Phosphorylation View All» Background Information: Rictor, the rapamycin-insensitive complex, is part of the mTORC2 kinase complex which is responsible for phosphorylating the hydrophobic motif kinase of Akt/PKB. This complex also includes mTOR, mSin1 and mLST8/GµL. mTORC2 is activated by growth factors and other mitogenic signals. View All» Species Reactivity:

• Human

• Rat
  View All» Species Reactivity Note: Demonstrated to react with Human. Predicted to react with Rat based on 100% sequence homology. View All» Control: Rictor protein immunoprecipitated from 293T cells transfected with either wildtype Rictor or mutant Rictor (S1219A) View All» Quality Assurance: Evaluated by Western Blot in Rictor protein immunoprecipitated from 293T cells transfected with either wildtype Rictor or mutant Rictor (S1219A).Western Blot Analysis: 1.25 µg/mL of this antibody detected Rictor on 10 µg of Rictor protein immunoprecipitated from 293T cells transfected with either wildtype Rictor or mutant Rictor (S1219A). View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: Q6R327 View All» Entrez Gene Number: NP_689969 View All» Gene Symbol: RICTOR View All» Alternate Names:
  • Rapamycin-insensitive companion of mTOR

  • AVO3 homolog

  • hAVO3
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications: Western Blotting View All» Entrez Gene Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM]. View All» UniProt Summary: FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development. SUBUNIT STRUCTURE: Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, LST8, PRR5, RICTOR and MAPKAP1. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Binds directly to MTOR and PRR5 within the TORC2 complex. May interact with PRR5L.PTM: Phosphorylated by MTOR; when part of mTORC2. SEQUENCE SIMILARITIES: Belongs to the pianissimo family.SEQUENCE CAUTION: The sequence CAH18135.1 differs from that shown. Reason: Wrong choice of CDS. View All» Product Name: Anti-phospho-Rictor (Ser1219) View All» Concentration: 0.25 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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