R&D Systems代理3625-IL-010 Recombinant Human IL-33 Protein (10 UG)

2025-06-27

货号:3625-IL-010

品牌:R&D Systems

规格:10ug

目录价:¥4490.00

市场价格:¥3592.00

会员价格:¥3592.00

  • 到货时间:3~4周

    金山科研平台,产品价格货期咨询微信:jinshanbio Source:E. coli-derived, Ser112-Thr270 Accession #:O95760 N-terminal Sequence Analysis:Ser112 Purity:>95%, by SDS-PAGE under reducing conditions and visualized by silver stain. Predicted Molecular Mass:18 kDa Activity:Measured in a cell proliferation assay using D10.G4.1 mouse helper T cells co-stimulated with anti-CD3. Schmitz, J. et al. (2005) Immunity 23:479.The ED50 for this effect is typically 0.06 - 0.24 ng/mL. This protein has also been shown to induce IL-13 secretion by D10.G4.1 cells under similar conditions.Optimal dilutions should be determined by each laboratory for each application. Molecule Information: IL-33 Long Name: Interleukin 33 Aliases: C9orf26; DVS27; NF-HEV Entrez Gene IDs: 90865 (Human); 77125 (Mouse) Background: IL-33

    View IL-33 IHC images. IL-33 is a proinflammatory protein that may also regulate gene transcription. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines and is constitutively expressed in smooth muscle and airway epithelia. It is upregulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1alpha or IL-1 beta stimulation. Similar to IL-1, IL-33 can be cleaved in vitro by caspase-1, generating an N-terminal fragment that is slightly shorter than the C-terminal fragment. The N-terminal portion of full length IL-33 contains a predicted bipartite nuclear localization sequence and a homeodomain-like helix-turn-helix DNA binding domain.

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