货号：07-1343

品牌：Merck Millipore

规格：EA

目录价：￥3024.00

市场价格：￥2570.40

会员价格：￥2419.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-phospho-B-Raf (Ser445) Antibody | 07-1343 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: Antibody recognizes B-Raf phosphorylated at and around Ser445. View All» Molecular Weight: 84 kDa View All» Epitope: Phosphorylated Ser445 View All» Immunogen: KLH-conjugated linear peptide corresponding to human B-Raf phosphorylated at and around Ser445. View All» Modifications: Phosphorylation View All» Background Information: The Raf proteins (Raf-1, A-Raf, B-Raf) are Ser/Thr kinases with homology to the PKC family, containing an N-terminal regulatory domain and a C-terminal catalytic domain. Members of the Raf family bind to activated Ras GTPase, which results in Raf translocation to the plasma membrane and activation. Activated Raf proteins phosphorylate MEKs, and are therefore the principle transducers of signals from Ras to MAP kinase. B-Raf acts as a signal transducer from membrane-associated receptors to nuclear transcription factors. B-Raf is important for the regulation of cell proliferation and determination of cell fate during embryogenesis. B-Raf acts downstream of Ras and upstream of MEK in the Ras-Raf-MEK-ERK signal transduction pathway, which is a conserved RAS-activated protein kinase cascade that regulates cell growth, proliferation, and differentiation in response to growth factors, cytokines, and hormones. View All» Species Reactivity:

• Mouse

• Rat

• Human

• Xenopus

• Chicken

• Canine

• Horse
  View All» Species Reactivity Note: Reacts with mouse and rat. Predicted to react with human, xenopus, chicken, dog and horse based on 100% sequence homology. View All» Control: NIH/3T3 untreated and PDGF treated cell lysates. View All» Quality Assurance: Evaluated by Western Blot in NIH/3T3 untreated and PDGF treated cell lysates.Western Blot Analysis: 2 µg/mL of this antibody detected phosphorylated B-Raf (Ser445) on NIH/3T3 cell lysates. View All» Purification Method: Affinity Purfied View All» Presentation: Purified Rabbit Serum in buffer containing 0.1 M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.05% sodium azide View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P15056 View All» Entrez Gene Number: NP_004324 View All» Gene Symbol: BRAF View All» Alternate Names:
  • B-RAF

  • B-Raf

  • BRAF1

  • p94

  • Raf

  • RAF
    View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:
    • Western Blotting

    • Enzyme Assay
      View All» Entrez Gene Summary: This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq] View All» UniProt Summary: B-Raf is involved in the transduction of mitogenic signals from the cell membrane to the nucleus. Defects in B-Raf are a cause of cardiofaciocutaneous syndrome (CFC syndrome) [MIM:115150]; also known as cardio-facio-cutaneous syndrome. CFC syndrome is characterized by a distinctive facial appearance, heart defects and mental retardation. Heart defects include pulmonic stenosis, atrial septal defects and hypertrophic cardiomyopathy. Some affected individuals present with ectodermal abnormalities such as sparse, friable hair, hyperkeratotic skin lesions and a generalized ichthyosis-like condition. Typical facial features are similar to Noonan syndrome. They include high forehead with bitemporal constriction, hypoplastic supraorbital ridges, downslanting palpebral fissures, a depressed nasal bridge, and posteriorly angulated ears with prominent helices. The inheritance of CFC syndrome is autosomal dominant. Defects in B-Raf are involved in a wide range of cancers and in non-Hodgkin lymphoma (NHL) [MIM:605027]. View All» Product Name: Anti-phospho-B-Raf (Ser445) View All» Concentration: 1 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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