货号：07-1352

品牌：Merck Millipore

规格：100Ug

目录价：￥5974.00

市场价格：￥5077.90

会员价格：￥4779.20

金山科研平台，产品价格货期咨询微信：jinshanbio Description: Anti-acetyl STAT5B (Lys701) Antibody | 07-1352 View All» Promotional Text: Special Shipping Offer on Antibodies100% Performance Guaranteed View All» Specificity: This antibody recognizes STAT5B acetylated at Lys701. View All» Molecular Weight: 90 kDa calculated View All» Epitope: Acetylated Lys701 View All» Immunogen: KLH-conjugated linear peptide corresponding to human STAT5B acetylated at Lys701. View All» Modifications: Acetylation View All» Background Information: STAT5B (signal transducers and activators of transcription 5b) controls the expression of early response genes and takes part in cytokine signaling. Studies have linked this protein to the inhibition of NFkappaB-mediated signaling. Additional studies have shown an association of STAT5B with regulation of lactation and growth, performance, and control of adipocyte function. Constitutively active STAT5B expression is often observed in a large number of leukemia’s and solid tumors. View All» Species Reactivity: Human View All» Species Reactivity Note: Demonstrated to react with Human. Other homologies: Rat and Mouse (91% sequence homology). View All» Application Notes: Western Blot Analysis: A representative lot was used by an independent laboratory in WB. (Ma, L., et al. (2010). Proc Natl Acad Sci U S A. 107(45):19314-19319.) View All» Control: Modified and non modified peptides of acetylated and non-acetylated STAT5B protein View All» Quality Assurance: Evaluated by Dot Blot in modified and non modified peptides of acetylated and non-acetylated STAT5B protein.Dot Blot Analysis: 1 µg/mL of this antibody detected STAT5B in modified and non modified peptides of acetylated and non-acetylated STAT5B protein. View All» Purification Method: Affinity purified View All» Presentation: Purified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide. View All» Storage Conditions: Stable for 1 year at 2-8°C from date of receipt. View All» UniProt Number: P51692 View All» Entrez Gene Number: NP_036580 View All» Gene Symbol: STAT5B View All» Alternate Names: Signal transducer and activator of transcription 5B View All» Usage Statement: Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals. View All» Key Applications:

• Dot Blot

• Western Blotting
  View All» UniProt Summary: FUNCTION: Carries out a dual function: signal transduction and activation of transcription. Binds to the GAS element and activates PRL-induced transcription.SUBUNIT STRUCTURE: Forms a homodimer or a heterodimer with a related family member. Binds NR3C1 (By similarity). Interacts with NCOA1, NMI and SOCS7. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note: Translocated into the nucleus in response to phosphorylation (By similarity).INVOLVEMENT IN DISEASE: Defects in STAT5B are the cause of Laron type dwarfism II (LTD2) [MIM:245590]; also known as Laron syndrome type II or Laron syndrome due to a post-receptor defect. The phenotypic features are consistent with growth hormone deficiency in the presence of normal to elevated circulating concentrations of growth hormone, and resistance to hexogeneous hormone therapy. SEQUENCE SIMILARITIES: Belongs to the transcription factor STAT family.Contains 1 SH2 domain. View All» Product Name: Anti-acetyl STAT5B (Lys701) View All» Concentration: 0.5 mg/mL View All» Antibody Type: Polyclonal Antibody View All» Qty/Pk: 100 μg View All» Format: Affinity Purified View All» Host: Rabbit View All»
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